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Page 1
Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis.
Ioerger TR, O'Malley T, Liao R, Guinn KM, Hickey MJ, Mohaideen N, Murphy KC, Boshoff HI, Mizrahi V, Rubin EJ, Sassetti CM, Barry CE 3rd, Sherman DR, Parish T, Sacchettini JC. Ioerger TR, et al. Among authors: parish t. PLoS One. 2013 Sep 23;8(9):e75245. doi: 10.1371/journal.pone.0075245. eCollection 2013. PLoS One. 2013. PMID: 24086479 Free PMC article.
A high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis.
Kumar A, Casey A, Odingo J, Kesicki EA, Abrahams G, Vieth M, Masquelin T, Mizrahi V, Hipskind PA, Sherman DR, Parish T. Kumar A, et al. Among authors: parish t. PLoS One. 2013 Nov 7;8(11):e72786. doi: 10.1371/journal.pone.0072786. eCollection 2013. PLoS One. 2013. PMID: 24244263 Free PMC article.
Identification of Phenoxyalkylbenzimidazoles with Antitubercular Activity.
Chandrasekera NS, Alling T, Bailey MA, Files M, Early JV, Ollinger J, Ovechkina Y, Masquelin T, Desai PV, Cramer JW, Hipskind PA, Odingo JO, Parish T. Chandrasekera NS, et al. Among authors: parish t. J Med Chem. 2015 Sep 24;58(18):7273-85. doi: 10.1021/acs.jmedchem.5b00546. Epub 2015 Sep 2. J Med Chem. 2015. PMID: 26295286
Oxadiazoles Have Butyrate-Specific Conditional Activity against Mycobacterium tuberculosis.
Early JV, Casey A, Martinez-Grau MA, Gonzalez Valcarcel IC, Vieth M, Ollinger J, Bailey MA, Alling T, Files M, Ovechkina Y, Parish T. Early JV, et al. Among authors: parish t. Antimicrob Agents Chemother. 2016 May 23;60(6):3608-16. doi: 10.1128/AAC.02896-15. Print 2016 Jun. Antimicrob Agents Chemother. 2016. PMID: 27044545 Free PMC article.
Synthesis and Evaluation of the 2-Aminothiazoles as Anti-Tubercular Agents.
Kesicki EA, Bailey MA, Ovechkina Y, Early JV, Alling T, Bowman J, Zuniga ES, Dalai S, Kumar N, Masquelin T, Hipskind PA, Odingo JO, Parish T. Kesicki EA, et al. Among authors: parish t. PLoS One. 2016 May 12;11(5):e0155209. doi: 10.1371/journal.pone.0155209. eCollection 2016. PLoS One. 2016. PMID: 27171280 Free PMC article.
A Target-Based Whole Cell Screen Approach To Identify Potential Inhibitors of Mycobacterium tuberculosis Signal Peptidase.
Bonnett SA, Ollinger J, Chandrasekera S, Florio S, O'Malley T, Files M, Jee JA, Ahn J, Casey A, Ovechkina Y, Roberts D, Korkegian A, Parish T. Bonnett SA, et al. Among authors: parish t. ACS Infect Dis. 2016 Dec 9;2(12):893-902. doi: 10.1021/acsinfecdis.6b00075. Epub 2016 Sep 19. ACS Infect Dis. 2016. PMID: 27642770 Free PMC article.
Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB.
Chandrasekera NS, Berube BJ, Shetye G, Chettiar S, O'Malley T, Manning A, Flint L, Awasthi D, Ioerger TR, Sacchettini J, Masquelin T, Hipskind PA, Odingo J, Parish T. Chandrasekera NS, et al. Among authors: parish t. ACS Infect Dis. 2017 Dec 8;3(12):898-916. doi: 10.1021/acsinfecdis.7b00112. Epub 2017 Oct 31. ACS Infect Dis. 2017. PMID: 29035551 Free PMC article.
272 results