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Page 1
Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state.
Miller PG, Sathappa M, Moroco JA, Jiang W, Qian Y, Iqbal S, Guo Q, Giacomelli AO, Shaw S, Vernier C, Bajrami B, Yang X, Raffier C, Sperling AS, Gibson CJ, Kahn J, Jin C, Ranaghan M, Caliman A, Brousseau M, Fischer ES, Lintner R, Piccioni F, Campbell AJ, Root DE, Garvie CW, Ebert BL. Miller PG, et al. Nat Commun. 2022 Jun 30;13(1):3778. doi: 10.1038/s41467-022-30463-9. Nat Commun. 2022. PMID: 35773251 Free PMC article.
PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.
Miller PG, Sperling AS, Mayerhofer C, McConkey ME, Ellegast JM, Da Silva C, Cohen DN, Wang C, Sharda A, Yan N, Saha S, Schluter C, Schechter I, Słabicki M, Sandoval B, Kahn J, Boettcher S, Gibson CJ, Scadden DT, Stegmaier K, Bhatt S, Lindsley RC, Ebert BL. Miller PG, et al. Blood. 2023 Dec 14;142(24):2079-2091. doi: 10.1182/blood.2023020331. Blood. 2023. PMID: 37595362 Free PMC article.
Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery Platform.
Jiang W, Shaw S, Rush J, Dumont N, Kim J, Singh R, Skepner A, Khodier C, Raffier C, Yan N, Schluter C, Yu X, Szuchnicki M, Sathappa M, Kahn J, Sperling AS, McKinney DC, Gould AE, Garvie CW, Miller PG. Jiang W, et al. bioRxiv [Preprint]. 2024 May 21:2024.05.20.595001. doi: 10.1101/2024.05.20.595001. bioRxiv. 2024. PMID: 38826457 Free PMC article. Preprint.
DNA Structure Design Is Improved Using an Artificially Expanded Alphabet of Base Pairs Including Loop and Mismatch Thermodynamic Parameters.
Pham TM, Miffin T, Sun H, Sharp KK, Wang X, Zhu M, Hoshika S, Peterson RJ, Benner SA, Kahn JD, Mathews DH. Pham TM, et al. Among authors: kahn jd. bioRxiv [Preprint]. 2023 Jun 8:2023.06.06.543917. doi: 10.1101/2023.06.06.543917. bioRxiv. 2023. Update in: ACS Synth Biol. 2023 Sep 15;12(9):2750-2763. doi: 10.1021/acssynbio.3c00358 PMID: 37333404 Free PMC article. Updated. Preprint.
Stability of the pH-Dependent Parallel-Stranded d(CGA) Motif.
Luteran EM, Kahn JD, Paukstelis PJ. Luteran EM, et al. Among authors: kahn jd. Biophys J. 2020 Oct 20;119(8):1580-1589. doi: 10.1016/j.bpj.2020.09.002. Epub 2020 Sep 11. Biophys J. 2020. PMID: 32966760 Free PMC article.
57 results