Translational repressor activity is equivalent and is quantitatively predicted by in vitro RNA binding for two iron-responsive element-binding proteins, IRP1 and IRP2.
Kim HY, Klausner RD, Rouault TA.
Kim HY, et al. Among authors: rouault ta.
J Biol Chem. 1995 Mar 10;270(10):4983-6. doi: 10.1074/jbc.270.10.4983.
J Biol Chem. 1995.
PMID: 7890603
Free article.
More recently, a second IRP has been identified that is expressed in all tissues and that binds IREs (Rouault, T. A., Haile, D. H., Downey, W. E., Philpott, C. C., Tang, C., Samaniego, F., Chin, J., Paul, I., Orloff, D., Harford, J. ...Chem. 269, 24252-24260; Samani …
More recently, a second IRP has been identified that is expressed in all tissues and that binds IREs (Rouault, T. A., Haile, D …