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Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk.
Zhu W, Buffa JA, Wang Z, Warrier M, Schugar R, Shih DM, Gupta N, Gregory JC, Org E, Fu X, Li L, DiDonato JA, Lusis AJ, Brown JM, Hazen SL. Zhu W, et al. Among authors: didonato ja. J Thromb Haemost. 2018 Sep;16(9):1857-1872. doi: 10.1111/jth.14234. Epub 2018 Aug 9. J Thromb Haemost. 2018. PMID: 29981269 Free PMC article.
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WH, DiDonato JA, Lusis AJ, Hazen SL. Wang Z, et al. Among authors: didonato ja. Nature. 2011 Apr 7;472(7341):57-63. doi: 10.1038/nature09922. Nature. 2011. PMID: 21475195 Free PMC article.
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis.
Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL. Koeth RA, et al. Among authors: didonato ja. Nat Med. 2013 May;19(5):576-85. doi: 10.1038/nm.3145. Epub 2013 Apr 7. Nat Med. 2013. PMID: 23563705 Free PMC article.
The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects.
Zamanian-Daryoush M, Lindner D, Tallant TC, Wang Z, Buffa J, Klipfell E, Parker Y, Hatala D, Parsons-Wingerter P, Rayman P, Yusufishaq MSS, Fisher EA, Smith JD, Finke J, DiDonato JA, Hazen SL. Zamanian-Daryoush M, et al. Among authors: didonato ja. J Biol Chem. 2013 Jul 19;288(29):21237-21252. doi: 10.1074/jbc.M113.468967. Epub 2013 May 17. J Biol Chem. 2013. PMID: 23720750 Free PMC article.
114 results