Larsen EM - Search Results

1

Fluorogenic structure activity library pinpoints molecular variations in substrate specificity of structurally homologous esterases.

White A, Koelper A, Russell A, Larsen EM, Kim C, Lavis LD, Hoops GC, Johnson RJ. White A, et al. Among authors: larsen em. J Biol Chem. 2018 Sep 7;293(36):13851-13862. doi: 10.1074/jbc.RA118.003972. Epub 2018 Jul 13. J Biol Chem. 2018. PMID: 30006352 Free PMC article.

2

In Vivo Delivery and Activation of Masked Fluorogenic Hydrolase Substrates by Endogenous Hydrolases in C. elegans.

Dube S, Dube H, Green NB, Larsen EM, White A, Johnson RJ, Kowalski JR. Dube S, et al. Among authors: larsen em. Chembiochem. 2017 Sep 19;18(18):1807-1813. doi: 10.1002/cbic.201700278. Epub 2017 Aug 7. Chembiochem. 2017. PMID: 28703362 Free PMC article.

3

Ester-prodrugs of ethambutol control its antibacterial activity and provide rapid screening for mycobacterial hydrolase activity.

Larsen EM, Stephens DC, Clarke NH, Johnson RJ. Larsen EM, et al. Bioorg Med Chem Lett. 2017 Oct 1;27(19):4544-4547. doi: 10.1016/j.bmcl.2017.08.057. Epub 2017 Aug 30. Bioorg Med Chem Lett. 2017. PMID: 28882482 Free PMC article.

4

Measuring the Global Substrate Specificity of Mycobacterial Serine Hydrolases Using a Library of Fluorogenic Ester Substrates.

Bassett B, Waibel B, White A, Hansen H, Stephens D, Koelper A, Larsen EM, Kim C, Glanzer A, Lavis LD, Hoops GC, Johnson RJ. Bassett B, et al. Among authors: larsen em. ACS Infect Dis. 2018 Jun 8;4(6):904-911. doi: 10.1021/acsinfecdis.7b00263. Epub 2018 Apr 16. ACS Infect Dis. 2018. PMID: 29648787 Free PMC article.

5

Microbial esterases and ester prodrugs: An unlikely marriage for combating antibiotic resistance.

Larsen EM, Johnson RJ. Larsen EM, et al. Drug Dev Res. 2019 Feb;80(1):33-47. doi: 10.1002/ddr.21468. Epub 2018 Oct 10. Drug Dev Res. 2019. PMID: 30302779 Free PMC article. Review.

6

Sequence and Structural Motifs Controlling the Broad Substrate Specificity of the Mycobacterial Hormone-Sensitive Lipase LipN.

Schemenauer DE, Pool EH, Raynor SN, Ruiz GP, Goehring LM, Koelper AJ, Wilson MA, Durand AJ Jr, Kourtoglou EC, Larsen EM, Lavis LD, Esteb JJ, Hoops GC, Johnson RJ. Schemenauer DE, et al. Among authors: larsen em. ACS Omega. 2023 Mar 30;8(14):13252-13264. doi: 10.1021/acsomega.3c00534. eCollection 2023 Apr 11. ACS Omega. 2023. PMID: 37065048 Free PMC article.

7

Conformation-activity relationships of polyketide natural products.

Larsen EM, Wilson MR, Taylor RE. Larsen EM, et al. Nat Prod Rep. 2015 Aug;32(8):1183-206. doi: 10.1039/c5np00014a. Nat Prod Rep. 2015. PMID: 25974024 Free PMC article. Review.

8

Conformational preferences of zampanolide and dactylolide.

Larsen EM, Wilson MR, Zajicek J, Taylor RE. Larsen EM, et al. Org Lett. 2013 Oct 18;15(20):5246-9. doi: 10.1021/ol402462h. Epub 2013 Oct 8. Org Lett. 2013. PMID: 24102367 Free PMC article.

9

Conformation-guided analogue design identifies potential antimalarial compounds through inhibition of mitochondrial respiration.

Larsen EM, Chang CF, Sakata-Kato T, Arico JW, Lombardo VM, Wirth DF, Taylor RE. Larsen EM, et al. Org Biomol Chem. 2018 Aug 1;16(30):5403-5406. doi: 10.1039/c8ob01257a. Org Biomol Chem. 2018. PMID: 30009295 Free PMC article.

10

Reduction of Feedback Inhibition in Homoserine Kinase (ThrB) of Corynebacterium glutamicum Enhances l-Threonine Biosynthesis.

Petit C, Kim Y, Lee SK, Brown J, Larsen E, Ronning DR, Suh JW, Kang CM. Petit C, et al. ACS Omega. 2018 Jan 31;3(1):1178-1186. doi: 10.1021/acsomega.7b01597. Epub 2018 Jan 29. ACS Omega. 2018. PMID: 30023797 Free PMC article.

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