Kranzusch PJ - Search Results

1

Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.

Zhou W, Whiteley AT, de Oliveira Mann CC, Morehouse BR, Nowak RP, Fischer ES, Gray NS, Mekalanos JJ, Kranzusch PJ. Zhou W, et al. Among authors: kranzusch pj. Cell. 2018 Jul 12;174(2):300-311.e11. doi: 10.1016/j.cell.2018.06.026. Cell. 2018. PMID: 30007416 Free PMC article.

2

Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity.

Kranzusch PJ, Lee AS, Berger JM, Doudna JA. Kranzusch PJ, et al. Cell Rep. 2013 May 30;3(5):1362-8. doi: 10.1016/j.celrep.2013.05.008. Epub 2013 May 23. Cell Rep. 2013. PMID: 23707061 Free PMC article.

3

cGAS dimerization entangles DNA recognition.

Kranzusch PJ, Vance RE. Kranzusch PJ, et al. Immunity. 2013 Dec 12;39(6):992-4. doi: 10.1016/j.immuni.2013.11.012. Immunity. 2013. PMID: 24332024 Free article.

4

Structure-guided reprogramming of human cGAS dinucleotide linkage specificity.

Kranzusch PJ, Lee ASY, Wilson SC, Solovykh MS, Vance RE, Berger JM, Doudna JA. Kranzusch PJ, et al. Cell. 2014 Aug 28;158(5):1011-1021. doi: 10.1016/j.cell.2014.07.028. Epub 2014 Aug 14. Cell. 2014. PMID: 25131990 Free PMC article.

5

Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.

Kranzusch PJ, Wilson SC, Lee AS, Berger JM, Doudna JA, Vance RE. Kranzusch PJ, et al. Mol Cell. 2015 Sep 17;59(6):891-903. doi: 10.1016/j.molcel.2015.07.022. Epub 2015 Aug 20. Mol Cell. 2015. PMID: 26300263 Free PMC article.

6

cGAS Conducts Micronuclei DNA Surveillance.

de Oliveira Mann CC, Kranzusch PJ. de Oliveira Mann CC, et al. Among authors: kranzusch pj. Trends Cell Biol. 2017 Oct;27(10):697-698. doi: 10.1016/j.tcb.2017.08.007. Epub 2017 Sep 4. Trends Cell Biol. 2017. PMID: 28882413

7

Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling.

Eaglesham JB, Pan Y, Kupper TS, Kranzusch PJ. Eaglesham JB, et al. Among authors: kranzusch pj. Nature. 2019 Feb;566(7743):259-263. doi: 10.1038/s41586-019-0928-6. Epub 2019 Feb 6. Nature. 2019. PMID: 30728498 Free PMC article.

8

Bacterial cGAS-like enzymes synthesize diverse nucleotide signals.

Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS, Lee ASY, Mekalanos JJ, Kranzusch PJ. Whiteley AT, et al. Among authors: kranzusch pj. Nature. 2019 Mar;567(7747):194-199. doi: 10.1038/s41586-019-0953-5. Epub 2019 Feb 20. Nature. 2019. PMID: 30787435 Free PMC article.

9

Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA.

Barnett KC, Coronas-Serna JM, Zhou W, Ernandes MJ, Cao A, Kranzusch PJ, Kagan JC. Barnett KC, et al. Among authors: kranzusch pj. Cell. 2019 Mar 7;176(6):1432-1446.e11. doi: 10.1016/j.cell.2019.01.049. Epub 2019 Feb 28. Cell. 2019. PMID: 30827685 Free PMC article.

10

Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation.

de Oliveira Mann CC, Orzalli MH, King DS, Kagan JC, Lee ASY, Kranzusch PJ. de Oliveira Mann CC, et al. Among authors: kranzusch pj. Cell Rep. 2019 Apr 23;27(4):1165-1175.e5. doi: 10.1016/j.celrep.2019.03.098. Cell Rep. 2019. PMID: 31018131 Free PMC article.

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