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Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme.
Triplett TA, Garrison KC, Marshall N, Donkor M, Blazeck J, Lamb C, Qerqez A, Dekker JD, Tanno Y, Lu WC, Karamitros CS, Ford K, Tan B, Zhang XM, McGovern K, Coma S, Kumada Y, Yamany MS, Sentandreu E, Fromm G, Tiziani S, Schreiber TH, Manfredi M, Ehrlich LIR, Stone E, Georgiou G. Triplett TA, et al. Among authors: schreiber th. Nat Biotechnol. 2018 Sep;36(8):758-764. doi: 10.1038/nbt.4180. Epub 2018 Jul 16. Nat Biotechnol. 2018. PMID: 30010674 Free PMC article.
Agonist redirected checkpoint, PD1-Fc-OX40L, for cancer immunotherapy.
Fromm G, de Silva S, Johannes K, Patel A, Hornblower JC, Schreiber TH. Fromm G, et al. Among authors: schreiber th. J Immunother Cancer. 2018 Dec 18;6(1):149. doi: 10.1186/s40425-018-0454-3. J Immunother Cancer. 2018. PMID: 30563566 Free PMC article.
LIGHT (TNFSF14) Costimulation Enhances Myeloid Cell Activation and Antitumor Immunity in the Setting of PD-1/PD-L1 and TIGIT Checkpoint Blockade.
Yoo KJ, Johannes K, González LE, Patel A, Shuptrine CW, Opheim Z, Lenz K, Campbell K, Nguyen TA, Miriyala J, Smith C, McGuire A, Tsai YH, Rangwala F, de Silva S, Schreiber TH, Fromm G. Yoo KJ, et al. Among authors: schreiber th. J Immunol. 2022 Aug 1;209(3):510-525. doi: 10.4049/jimmunol.2101175. Epub 2022 Jul 11. J Immunol. 2022. PMID: 35817517 Free PMC article.
Cutting Edge: Bispecific γδ T Cell Engager Containing Heterodimeric BTN2A1 and BTN3A1 Promotes Targeted Activation of Vγ9Vδ2+ T Cells in the Presence of Costimulation by CD28 or NKG2D.
Lai AY, Patel A, Brewer F, Evans K, Johannes K, González LE, Yoo KJ, Fromm G, Wilson K, Schreiber TH, de Silva S. Lai AY, et al. Among authors: schreiber th. J Immunol. 2022 Oct 15;209(8):1475-1480. doi: 10.4049/jimmunol.2200185. Epub 2022 Sep 12. J Immunol. 2022. PMID: 36096643 Free PMC article.
Lipid-Encapsulated mRNAs Encoding Complex Fusion Proteins Potentiate Antitumor Immune Responses.
Shuptrine CW, Chen Y, Miriyala J, Lenz K, Moffett D, Nguyen TA, Michaux J, Campbell K, Smith C, Morra M, Rivera-Molina Y, Murr N, Cooper S, McGuire A, Makani V, Oien N, Zugates JT, de Silva S, Schreiber TH, de Picciotto S, Fromm G. Shuptrine CW, et al. Among authors: schreiber th. Cancer Res. 2024 May 15;84(10):1550-1559. doi: 10.1158/0008-5472.CAN-23-2875. Cancer Res. 2024. PMID: 38381555 Free PMC article.
Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection.
Hatfield SM, Kjaergaard J, Lukashev D, Belikoff B, Schreiber TH, Sethumadhavan S, Abbott R, Philbrook P, Thayer M, Shujia D, Rodig S, Kutok JL, Ren J, Ohta A, Podack ER, Karger B, Jackson EK, Sitkovsky M. Hatfield SM, et al. Among authors: schreiber th. J Mol Med (Berl). 2014 Dec;92(12):1283-92. doi: 10.1007/s00109-014-1189-3. Epub 2014 Aug 15. J Mol Med (Berl). 2014. PMID: 25120128 Free PMC article.
36 results