Leonard WJ - Search Results

1

Act1 is a negative regulator in T and B cells via direct inhibition of STAT3.

Zhang CJ, Wang C, Jiang M, Gu C, Xiao J, Chen X, Martin BN, Tang F, Yamamoto E, Xian Y, Wang H, Li F, Sartor RB, Smith H, Husni ME, Shi FD, Gao J, Carman J, Dongre A, McKarns SC, Coppieters K, Jørgensen TN, Leonard WJ, Li X. Zhang CJ, et al. Among authors: leonard wj. Nat Commun. 2018 Jul 16;9(1):2745. doi: 10.1038/s41467-018-04974-3. Nat Commun. 2018. PMID: 30013031 Free PMC article.

2

Heterodimerization of the IL-2 receptor beta- and gamma-chain cytoplasmic domains is required for signalling.

Nakamura Y, Russell SM, Mess SA, Friedmann M, Erdos M, Francois C, Jacques Y, Adelstein S, Leonard WJ. Nakamura Y, et al. Among authors: leonard wj. Nature. 1994 May 26;369(6478):330-3. doi: 10.1038/369330a0. Nature. 1994. PMID: 8183373

3

GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cells.

Xue HH, Bollenbacher J, Rovella V, Tripuraneni R, Du YB, Liu CY, Williams A, McCoy JP, Leonard WJ. Xue HH, et al. Among authors: leonard wj. Nat Immunol. 2004 Oct;5(10):1036-44. doi: 10.1038/ni1117. Epub 2004 Sep 7. Nat Immunol. 2004. PMID: 15361867

4

Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression.

Liao W, Schones DE, Oh J, Cui Y, Cui K, Roh TY, Zhao K, Leonard WJ. Liao W, et al. Among authors: leonard wj. Nat Immunol. 2008 Nov;9(11):1288-96. doi: 10.1038/ni.1656. Epub 2008 Sep 28. Nat Immunol. 2008. PMID: 18820682 Free PMC article.

5

Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors.

Kwon H, Thierry-Mieg D, Thierry-Mieg J, Kim HP, Oh J, Tunyaplin C, Carotta S, Donovan CE, Goldman ML, Tailor P, Ozato K, Levy DE, Nutt SL, Calame K, Leonard WJ. Kwon H, et al. Among authors: leonard wj. Immunity. 2009 Dec 18;31(6):941-52. doi: 10.1016/j.immuni.2009.10.008. Immunity. 2009. PMID: 20064451 Free PMC article.

6

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages.

Liao W, Lin JX, Wang L, Li P, Leonard WJ. Liao W, et al. Among authors: leonard wj. Nat Immunol. 2011 Jun;12(6):551-9. doi: 10.1038/ni.2030. Epub 2011 Apr 24. Nat Immunol. 2011. PMID: 21516110 Free PMC article.

7

BATF-JUN is critical for IRF4-mediated transcription in T cells.

Li P, Spolski R, Liao W, Wang L, Murphy TL, Murphy KM, Leonard WJ. Li P, et al. Among authors: leonard wj. Nature. 2012 Oct 25;490(7421):543-6. doi: 10.1038/nature11530. Epub 2012 Sep 19. Nature. 2012. PMID: 22992523 Free PMC article.

8

Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions.

Yoshizaki A, Miyagaki T, DiLillo DJ, Matsushita T, Horikawa M, Kountikov EI, Spolski R, Poe JC, Leonard WJ, Tedder TF. Yoshizaki A, et al. Among authors: leonard wj. Nature. 2012 Nov 8;491(7423):264-8. doi: 10.1038/nature11501. Epub 2012 Oct 14. Nature. 2012. PMID: 23064231 Free PMC article.

9

Interleukin-21: a double-edged sword with therapeutic potential.

Spolski R, Leonard WJ. Spolski R, et al. Among authors: leonard wj. Nat Rev Drug Discov. 2014 May;13(5):379-95. doi: 10.1038/nrd4296. Epub 2014 Apr 22. Nat Rev Drug Discov. 2014. PMID: 24751819 Review.

10

Autoimmunity: regulatory B cells--IL-35 and IL-21 regulate the regulators.

Tedder TF, Leonard WJ. Tedder TF, et al. Among authors: leonard wj. Nat Rev Rheumatol. 2014 Aug;10(8):452-3. doi: 10.1038/nrrheum.2014.95. Epub 2014 Jun 17. Nat Rev Rheumatol. 2014. PMID: 24934192 Free PMC article.

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