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Act1 is a negative regulator in T and B cells via direct inhibition of STAT3.
Zhang CJ, Wang C, Jiang M, Gu C, Xiao J, Chen X, Martin BN, Tang F, Yamamoto E, Xian Y, Wang H, Li F, Sartor RB, Smith H, Husni ME, Shi FD, Gao J, Carman J, Dongre A, McKarns SC, Coppieters K, Jørgensen TN, Leonard WJ, Li X. Zhang CJ, et al. Among authors: mckarns sc. Nat Commun. 2018 Jul 16;9(1):2745. doi: 10.1038/s41467-018-04974-3. Nat Commun. 2018. PMID: 30013031 Free PMC article.
Differential regulation of hepatic organic cation transporter 1, organic anion-transporting polypeptide 1a4, bile-salt export pump, and multidrug resistance-associated protein 2 transporter expression in lymphocyte-deficient mice associates with interleukin-6 production.
Bodeman CE, Dzierlenga AL, Tally CM, Mulligan RM, Lake AD, Cherrington NJ, McKarns SC. Bodeman CE, et al. Among authors: mckarns sc. J Pharmacol Exp Ther. 2013 Oct;347(1):136-44. doi: 10.1124/jpet.113.205369. Epub 2013 Aug 8. J Pharmacol Exp Ther. 2013. PMID: 23929842 Free PMC article.
Immunotoxicology: fifty years of global scientific progress.
McKarns SC, Kerkvliet NI, Dean JH, Bonn MB, Cohen MD, Franko J, Laiosa MD, Lawrence BP, Luebke RW, Luster MI, Miller PG, Palmer RK, Pfau JC, Raman P, Regal JF, Rodgers KE, Schondelmeyer RS, Zhang X, Burns-Naas LA. McKarns SC, et al. J Immunotoxicol. 2012 Oct-Dec;9(4):339-40. doi: 10.3109/1547691X.2012.658530. Epub 2012 Oct 19. J Immunotoxicol. 2012. PMID: 23078377 Free article.
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