Wang X - Search Results

1

Absorption, metabolism, and excretion of the antiemetic rolapitant, a selective neurokinin-1 receptor antagonist, in healthy male subjects.

Zhang ZY, Wang J, Kansra V, Wang X. Zhang ZY, et al. Among authors: wang x, wang j. Invest New Drugs. 2019 Feb;37(1):139-146. doi: 10.1007/s10637-018-0638-1. Epub 2018 Jul 21. Invest New Drugs. 2019. PMID: 30032410 Clinical Trial.

2

Derivation of Phase 3 dosing for peginterferon lambda-1a in chronic hepatitis C, Part 2: Exposure-response analyses for efficacy and safety variables.

Hruska M, Wang X, Chan P, Ahmad A, Freeman J, Horga MA, Hillson J, Kansra V, Lopez-Talavera JC. Hruska M, et al. Among authors: wang x. J Clin Pharmacol. 2015 Jan;55(1):73-80. doi: 10.1002/jcph.361. Epub 2014 Jul 24. J Clin Pharmacol. 2015. PMID: 25042797 Clinical Trial.

3

Derivation of Phase 3 dosing for peginterferon lambda-1a in chronic hepatitis C, Part 1: Modeling optimal treatment duration and sustained virologic response rates.

Wang X, Hruska M, Chan P, Ahmad A, Freeman J, Horga MA, Hillson J, Kansra V, Lopez-Talavera JC. Wang X, et al. J Clin Pharmacol. 2015 Jan;55(1):63-72. doi: 10.1002/jcph.363. Epub 2014 Jul 24. J Clin Pharmacol. 2015. PMID: 25043197 Clinical Trial.

4

Integrated safety analysis of rolapitant with coadministered drugs from phase II/III trials: an assessment of CYP2D6 or BCRP inhibition by rolapitant.

Barbour S, Smit T, Wang X, Powers D, Arora S, Kansra V, Aapro M, Herrstedt J. Barbour S, et al. Among authors: wang x. Ann Oncol. 2017 Jun 1;28(6):1268-1273. doi: 10.1093/annonc/mdx073. Ann Oncol. 2017. PMID: 28327932 Free PMC article. Clinical Trial.

5

Effects of Rolapitant Administered Intravenously or Orally on the Pharmacokinetics of Digoxin (P-glycoprotein Substrate) and Sulfasalazine (Breast Cancer Resistance Protein Substrate) in Healthy Volunteers.

Wang X, Zhang ZY, Arora S, Hughes L, Wang J, Powers D, Christensen J, Lu S, Kansra V. Wang X, et al. Among authors: wang j. J Clin Pharmacol. 2018 Feb;58(2):202-211. doi: 10.1002/jcph.1005. Epub 2017 Sep 14. J Clin Pharmacol. 2018. PMID: 28906558 Clinical Trial.

6

Bioequivalence of Intravenous and Oral Rolapitant: Results From a Randomized, Open-Label Pivotal Study.

Wang X, Zhang ZY, Powers D, Wang J, Lu S, Arora S, Hughes L, Christensen J, Kansra V. Wang X, et al. Among authors: wang j. J Clin Pharmacol. 2017 Dec;57(12):1600-1606. doi: 10.1002/jcph.966. Epub 2017 Sep 14. J Clin Pharmacol. 2017. PMID: 28906561 Clinical Trial.

7

Pharmacokinetics of Rolapitant in Patients With Mild to Moderate Hepatic Impairment.

Wang J, Wang X, Zhang ZY, Arora S, Lu S, Kansra V. Wang J, et al. Among authors: wang x. J Clin Pharmacol. 2018 May;58(5):686-693. doi: 10.1002/jcph.1066. Epub 2018 Jan 12. J Clin Pharmacol. 2018. PMID: 29329482 Clinical Trial.

8

Effects of Rolapitant Administered Intravenously on the Pharmacokinetics of a Modified Cooperstown Cocktail (Midazolam, Omeprazole, Warfarin, Caffeine, and Dextromethorphan) in Healthy Subjects.

Wang X, Zhang ZY, Arora S, Wang J, Lu S, Powers D, Kansra V. Wang X, et al. Among authors: wang j. J Clin Pharmacol. 2018 Aug;58(8):1074-1083. doi: 10.1002/jcph.1114. Epub 2018 Apr 25. J Clin Pharmacol. 2018. PMID: 29693712

9

Pharmacokinetics, Safety, and Tolerability of Rolapitant Administered Intravenously Following Single Ascending and Multiple Ascending Doses in Healthy Subjects.

Wang X, Zhang ZY, Wang J, Powers D, Arora S, Lu S, Kansra V. Wang X, et al. Among authors: wang j. Clin Pharmacol Drug Dev. 2019 Feb;8(2):160-171. doi: 10.1002/cpdd.580. Epub 2018 Jun 15. Clin Pharmacol Drug Dev. 2019. PMID: 29905976 Clinical Trial.

10

Effects of rolapitant administered orally on the pharmacokinetics of dextromethorphan (CYP2D6), tolbutamide (CYP2C9), omeprazole (CYP2C19), efavirenz (CYP2B6), and repaglinide (CYP2C8) in healthy subjects.

Wang J, Zhang ZY, Lu S, Powers D, Kansra V, Wang X. Wang J, et al. Among authors: wang x. Support Care Cancer. 2019 Mar;27(3):819-827. doi: 10.1007/s00520-018-4331-x. Epub 2018 Aug 6. Support Care Cancer. 2019. PMID: 30084103 Free PMC article. Clinical Trial.

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