van der Graaf PH - Search Results

1

In vitro and in silico analysis of the effects of D₂ receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations.

de Witte WEA, Versfelt JW, Kuzikov M, Rolland S, Georgi V, Gribbon P, Gul S, Huntjens D, van der Graaf PH, Danhof M, Fernández-Montalván A, Witt G, de Lange ECM. de Witte WEA, et al. Among authors: van der graaf ph. Br J Pharmacol. 2018 Nov;175(21):4121-4136. doi: 10.1111/bph.14456. Epub 2018 Sep 21. Br J Pharmacol. 2018. PMID: 30051456 Free PMC article.

2

Exposure and characterization of the action of noradrenaline at dopamine receptors mediating endothelium-independent relaxation of rat isolated small mesenteric arteries.

Van der Graaf PH, Saxena PR, Shankley NP, Black JW. Van der Graaf PH, et al. Br J Pharmacol. 1995 Dec;116(8):3237-42. doi: 10.1111/j.1476-5381.1995.tb15130.x. Br J Pharmacol. 1995. PMID: 8719802 Free PMC article.

3

Analysis of drug-receptor interactions in vivo: a new approach in pharmacokinetic-pharmacodynamic modelling.

Van der Graaf PH, Danhof M. Van der Graaf PH, et al. Int J Clin Pharmacol Ther. 1997 Oct;35(10):442-6. Int J Clin Pharmacol Ther. 1997. PMID: 9352393 Review.

4

Mechanism-based pharmacokinetic-pharmacodynamic modeling of the effects of N6-cyclopentyladenosine analogs on heart rate in rat: estimation of in vivo operational affinity and efficacy at adenosine A1 receptors.

Van Der Graaf PH, Van Schaick EA, Math-ot RA, Ijzerman AP, Danhof M. Van Der Graaf PH, et al. Among authors: van schaick ea. J Pharmacol Exp Ther. 1997 Nov;283(2):809-16. J Pharmacol Exp Ther. 1997. PMID: 9353402

5

On the reliability of affinity and efficacy estimates obtained by direct operational model fitting of agonist concentration-effect curves following irreversible receptor inactivation.

Van der Graaf PH, Danhof M. Van der Graaf PH, et al. J Pharmacol Toxicol Methods. 1997 Oct;38(2):81-5. doi: 10.1016/s1056-8719(97)00052-x. J Pharmacol Toxicol Methods. 1997. PMID: 9403778

6

Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of synthetic opioids in the rat: correlation with the interaction at the mu-opioid receptor.

Cox EH, Kerbusch T, Van der Graaf PH, Danhof M. Cox EH, et al. Among authors: van der graaf ph. J Pharmacol Exp Ther. 1998 Mar;284(3):1095-103. J Pharmacol Exp Ther. 1998. PMID: 9495871

7

Multivariate quantitative structure-pharmacokinetic relationships (QSPKR) analysis of adenosine A1 receptor agonists in rat.

Van der Graaf PH, Nilsson J, Van Schaick EA, Danhof M. Van der Graaf PH, et al. Among authors: van schaick ea. J Pharm Sci. 1999 Mar;88(3):306-12. doi: 10.1021/js980294a. J Pharm Sci. 1999. PMID: 10052988

8

Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: prediction of tissue-dependent efficacy in vivo.

Van der Graaf PH, Van Schaick EA, Visser SA, De Greef HJ, Ijzerman AP, Danhof M. Van der Graaf PH, et al. Among authors: van schaick ea. J Pharmacol Exp Ther. 1999 Aug;290(2):702-9. J Pharmacol Exp Ther. 1999. PMID: 10411581

9

Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy.

Cleton A, Van der Graaf PH, Ghijsen W, Voskuyl R, Danhof M. Cleton A, et al. Among authors: van der graaf ph. Pharm Res. 1999 Nov;16(11):1702-9. doi: 10.1023/a:1018949914532. Pharm Res. 1999. PMID: 10571275

10

Enantioselective high-performance liquid chromatographic analysis of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin. Application to a pharmacokinetic-pharmacodynamic study in rats.

Zuideveld KP, Treijtel N, Van der Graaf PH, Danhof M. Zuideveld KP, et al. Among authors: van der graaf ph. J Chromatogr B Biomed Sci Appl. 2000 Jan 28;738(1):67-73. doi: 10.1016/s0378-4347(99)00493-4. J Chromatogr B Biomed Sci Appl. 2000. PMID: 10778927

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