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Rtt105 functions as a chaperone for replication protein A to preserve genome stability.
Li S, Xu Z, Xu J, Zuo L, Yu C, Zheng P, Gan H, Wang X, Li L, Sharma S, Chabes A, Li D, Wang S, Zheng S, Li J, Chen X, Sun Y, Xu D, Han J, Chan K, Qi Z, Feng J, Li Q. Li S, et al. Among authors: chan k. EMBO J. 2018 Sep 3;37(17):e99154. doi: 10.15252/embj.201899154. Epub 2018 Jul 31. EMBO J. 2018. PMID: 30065069 Free PMC article.
Mechanism of cancer: Oncohistones in action.
Qiu L, Hu X, Jing Q, Zeng X, Chan KM, Han J. Qiu L, et al. J Genet Genomics. 2018 May 20;45(5):227-236. doi: 10.1016/j.jgg.2018.04.004. Epub 2018 Apr 30. J Genet Genomics. 2018. PMID: 29804713 Review.
Cancer-associated histone mutation H2BG53D disrupts DNA-histone octamer interaction and promotes oncogenic phenotypes.
Wan YCE, Leung TCS, Ding D, Sun X, Liu J, Zhu L, Kang TZE, Yang D, Zhang Y, Zhang J, Qian C, Huen MSY, Li Q, Chow MZY, Zheng Z, Han J, Goel A, Wang X, Ishibashi T, Chan KM. Wan YCE, et al. Signal Transduct Target Ther. 2020 Mar 6;5(1):27. doi: 10.1038/s41392-020-0131-0. Signal Transduct Target Ther. 2020. PMID: 32296031 Free PMC article. No abstract available.
Impaired histone inheritance promotes tumor progression.
Tian C, Zhou J, Li X, Gao Y, Wen Q, Kang X, Wang N, Yao Y, Jiang J, Song G, Zhang T, Hu S, Liao J, Yu C, Wang Z, Liu X, Pei X, Chan K, Liu Z, Gan H. Tian C, et al. Among authors: chan k. Nat Commun. 2023 Jun 10;14(1):3429. doi: 10.1038/s41467-023-39185-y. Nat Commun. 2023. PMID: 37301892 Free PMC article.
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