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A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells.
Vakulskas CA, Dever DP, Rettig GR, Turk R, Jacobi AM, Collingwood MA, Bode NM, McNeill MS, Yan S, Camarena J, Lee CM, Park SH, Wiebking V, Bak RO, Gomez-Ospina N, Pavel-Dinu M, Sun W, Bao G, Porteus MH, Behlke MA. Vakulskas CA, et al. Among authors: porteus mh. Nat Med. 2018 Aug;24(8):1216-1224. doi: 10.1038/s41591-018-0137-0. Epub 2018 Aug 6. Nat Med. 2018. PMID: 30082871 Free PMC article.
Gene editing: not just for translation anymore.
McMahon MA, Rahdar M, Porteus M. McMahon MA, et al. Nat Methods. 2011 Dec 28;9(1):28-31. doi: 10.1038/nmeth.1811. Nat Methods. 2011. PMID: 22205513 No abstract available.
Receptor-mediated delivery of engineered nucleases for genome modification.
Chen Z, Jaafar L, Agyekum DG, Xiao H, Wade MF, Kumaran RI, Spector DL, Bao G, Porteus MH, Dynan WS, Meiler SE. Chen Z, et al. Among authors: porteus mh. Nucleic Acids Res. 2013 Oct;41(19):e182. doi: 10.1093/nar/gkt710. Epub 2013 Aug 16. Nucleic Acids Res. 2013. PMID: 23956220 Free PMC article.
SAPTA: a new design tool for improving TALE nuclease activity.
Lin Y, Fine EJ, Zheng Z, Antico CJ, Voit RA, Porteus MH, Cradick TJ, Bao G. Lin Y, et al. Among authors: porteus mh. Nucleic Acids Res. 2014 Apr;42(6):e47. doi: 10.1093/nar/gkt1363. Epub 2014 Jan 16. Nucleic Acids Res. 2014. PMID: 24442582 Free PMC article.
Quantifying on- and off-target genome editing.
Hendel A, Fine EJ, Bao G, Porteus MH. Hendel A, et al. Among authors: porteus mh. Trends Biotechnol. 2015 Feb;33(2):132-40. doi: 10.1016/j.tibtech.2014.12.001. Epub 2015 Jan 13. Trends Biotechnol. 2015. PMID: 25595557 Free PMC article. Review.
Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells.
Hendel A, Bak RO, Clark JT, Kennedy AB, Ryan DE, Roy S, Steinfeld I, Lunstad BD, Kaiser RJ, Wilkens AB, Bacchetta R, Tsalenko A, Dellinger D, Bruhn L, Porteus MH. Hendel A, et al. Among authors: porteus mh. Nat Biotechnol. 2015 Sep;33(9):985-989. doi: 10.1038/nbt.3290. Epub 2015 Jun 29. Nat Biotechnol. 2015. PMID: 26121415 Free PMC article.
Knock-in editing: it functionally corrects!
Porteus MH. Porteus MH. Blood. 2016 May 26;127(21):2507-9. doi: 10.1182/blood-2016-03-703181. Blood. 2016. PMID: 27231391 Free PMC article.
CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells.
Dever DP, Bak RO, Reinisch A, Camarena J, Washington G, Nicolas CE, Pavel-Dinu M, Saxena N, Wilkens AB, Mantri S, Uchida N, Hendel A, Narla A, Majeti R, Weinberg KI, Porteus MH. Dever DP, et al. Among authors: porteus mh. Nature. 2016 Nov 17;539(7629):384-389. doi: 10.1038/nature20134. Epub 2016 Nov 7. Nature. 2016. PMID: 27820943 Free PMC article.
190 results