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Metallothionein-I/II expression associates with the astrocyte DNA damage response and not Alzheimer-type pathology in the aging brain.
Waller R, Murphy M, Garwood CJ, Jennings L, Heath PR, Chambers A, Matthews FE, Brayne C, Ince PG, Wharton SB, Simpson JE; Cognitive Function and Ageing Neuropathology Study Group. Waller R, et al. Among authors: ince pg. Glia. 2018 Nov;66(11):2316-2323. doi: 10.1002/glia.23465. Epub 2018 Aug 10. Glia. 2018. PMID: 30098078
Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype.
Simpson JE, Ince PG, Shaw PJ, Heath PR, Raman R, Garwood CJ, Gelsthorpe C, Baxter L, Forster G, Matthews FE, Brayne C, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group. Simpson JE, et al. Among authors: ince pg. Neurobiol Aging. 2011 Oct;32(10):1795-807. doi: 10.1016/j.neurobiolaging.2011.04.013. Epub 2011 Jun 25. Neurobiol Aging. 2011. PMID: 21705112
DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: a population-based study in the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort.
Garwood CJ, Simpson JE, Al Mashhadi S, Axe C, Wilson S, Heath PR, Shaw PJ, Matthews FE, Brayne C, Ince PG, Wharton SB; MRC Cognitive Function and Ageing Study. Garwood CJ, et al. Among authors: ince pg. Neuropathol Appl Neurobiol. 2014 Dec;40(7):802-14. doi: 10.1111/nan.12156. Neuropathol Appl Neurobiol. 2014. PMID: 24861546
Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain.
Al-Mashhadi S, Simpson JE, Heath PR, Dickman M, Forster G, Matthews FE, Brayne C, Ince PG, Wharton SB; Medical Research Council Cognitive Function and Ageing Study. Al-Mashhadi S, et al. Among authors: ince pg. Brain Pathol. 2015 Sep;25(5):565-74. doi: 10.1111/bpa.12216. Epub 2014 Nov 20. Brain Pathol. 2015. PMID: 25311358 Free PMC article.
A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort.
Simpson JE, Ince PG, Matthews FE, Shaw PJ, Heath PR, Brayne C, Garwood C, Higginbottom A, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group. Simpson JE, et al. Among authors: ince pg. Neuropathol Appl Neurobiol. 2015 Jun;41(4):483-96. doi: 10.1111/nan.12202. Epub 2015 Apr 23. Neuropathol Appl Neurobiol. 2015. PMID: 25443110 Free PMC article.
Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology.
Simpson JE, Ince PG, Minett T, Matthews FE, Heath PR, Shaw PJ, Goodall E, Garwood CJ, Ratcliffe LE, Brayne C, Rattray M, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group. Simpson JE, et al. Among authors: ince pg. Neuropathol Appl Neurobiol. 2016 Feb;42(2):167-79. doi: 10.1111/nan.12252. Epub 2015 Jul 7. Neuropathol Appl Neurobiol. 2016. PMID: 26095650 Free PMC article.
The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain.
Fluteau A, Ince PG, Minett T, Matthews FE, Brayne C, Garwood CJ, Ratcliffe LE, Morgan S, Heath PR, Shaw PJ, Wharton SB, Simpson JE; MRC Cognitive Function Ageing Neuropathology Study Group. Fluteau A, et al. Among authors: ince pg. Neurosci Lett. 2015 Nov 16;609:11-7. doi: 10.1016/j.neulet.2015.10.001. Epub 2015 Oct 8. Neurosci Lett. 2015. PMID: 26455863 Free PMC article.
Advanced Glycation End Product Formation in Human Cerebral Cortex Increases With Alzheimer-Type Neuropathologic Changes but Is Not Independently Associated With Dementia in a Population-Derived Aging Brain Cohort.
Chambers A, Bury JJ, Minett T, Richardson CD, Brayne C, Ince PG, Shaw PJ, Garwood CJ, Heath PR, Simpson JE, Matthews FE, Wharton SB. Chambers A, et al. Among authors: ince pg. J Neuropathol Exp Neurol. 2020 Sep 1;79(9):950-958. doi: 10.1093/jnen/nlaa064. J Neuropathol Exp Neurol. 2020. PMID: 32766675
Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer's and small vessel disease pathologies.
Waller R, Narramore R, Simpson JE, Heath PR, Verma N, Tinsley M, Barnes JR, Haris HT, Henderson FE, Matthews FE, Richardson CD, Brayne C, Ince PG, Kalaria RN, Wharton SB; CFAS. Waller R, et al. Among authors: ince pg. Brain Pathol. 2021 May;31(3):e12928. doi: 10.1111/bpa.12928. Epub 2021 Feb 15. Brain Pathol. 2021. PMID: 33336479 Free PMC article.
302 results