Paik S - Search Results

1

Pyrazinyl ureas revisited: 1-(3-(Benzyloxy)pyrazin-2-yl)-3-(3,4-dichlorophenyl)urea, a new blocker of Aβ-induced mPTP opening for Alzheimer's disease.

Elkamhawy A, Park JE, Hassan AHE, Pae AN, Lee J, Paik S, Park BG, Roh EJ. Elkamhawy A, et al. Among authors: paik s. Eur J Med Chem. 2018 Sep 5;157:268-278. doi: 10.1016/j.ejmech.2018.07.068. Epub 2018 Jul 31. Eur J Med Chem. 2018. PMID: 30098482

2

Design, synthesis, biological evaluation and molecular modelling of 2-(2-aryloxyphenyl)-1,4-dihydroisoquinolin-3(2H)-ones: A novel class of TSPO ligands modulating amyloid-β-induced mPTP opening.

Elkamhawy A, Park JE, Hassan AHE, Pae AN, Lee J, Park BG, Paik S, Do J, Park JH, Park KD, Moon B, Park WK, Cho H, Jeong DY, Roh EJ. Elkamhawy A, et al. Among authors: paik s. Eur J Pharm Sci. 2017 Jun 15;104:366-381. doi: 10.1016/j.ejps.2017.04.015. Epub 2017 Apr 21. Eur J Pharm Sci. 2017. PMID: 28435076

3

Synthesis and evaluation of new pyridyl/pyrazinyl thiourea derivatives: Neuroprotection against amyloid-β-induced toxicity.

Park JE, Elkamhawy A, Hassan AHE, Pae AN, Lee J, Paik S, Park BG, Roh EJ. Park JE, et al. Among authors: paik s. Eur J Med Chem. 2017 Dec 1;141:322-334. doi: 10.1016/j.ejmech.2017.09.043. Epub 2017 Sep 22. Eur J Med Chem. 2017. PMID: 29031076

4

Hit discovery of 4-amino-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide: A novel EGFR inhibitor from a designed small library.

Elkamhawy A, Paik S, Hassan AHE, Lee YS, Roh EJ. Elkamhawy A, et al. Among authors: paik s. Bioorg Chem. 2017 Dec;75:393-405. doi: 10.1016/j.bioorg.2017.10.009. Epub 2017 Nov 5. Bioorg Chem. 2017. PMID: 29102722

5

Repositioning of the antipsychotic trifluoperazine: Synthesis, biological evaluation and in silico study of trifluoperazine analogs as anti-glioblastoma agents.

Kang S, Lee JM, Jeon B, Elkamhawy A, Paik S, Hong J, Oh SJ, Paek SH, Lee CJ, Hassan AHE, Kang SS, Roh EJ. Kang S, et al. Among authors: paik s. Eur J Med Chem. 2018 May 10;151:186-198. doi: 10.1016/j.ejmech.2018.03.055. Epub 2018 Mar 23. Eur J Med Chem. 2018. PMID: 29614416

6

EGFR inhibitors from cancer to inflammation: Discovery of 4-fluoro-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide as a novel anti-inflammatory EGFR inhibitor.

Elkamhawy A, Hassan AHE, Paik S, Sup Lee Y, Lee HH, Shin JS, Lee KT, Roh EJ. Elkamhawy A, et al. Among authors: paik s. Bioorg Chem. 2019 May;86:112-118. doi: 10.1016/j.bioorg.2019.01.017. Epub 2019 Jan 12. Bioorg Chem. 2019. PMID: 30685642

7

Optimization study towards more potent thiazolidine-2,4-dione IKK-β modulator: Synthesis, biological evaluation and in silico docking simulation.

Elkamhawy A, Youn Kim N, Hassan AHE, Park JE, Yang JE, Elsherbeny MH, Paik S, Oh KS, Lee BH, Lee MY, Shin KJ, Pae AN, Lee KT, Roh EJ. Elkamhawy A, et al. Among authors: paik s. Bioorg Chem. 2019 Nov;92:103261. doi: 10.1016/j.bioorg.2019.103261. Epub 2019 Sep 7. Bioorg Chem. 2019. PMID: 31542718

8

Thiazolidine-2,4-dione-based irreversible allosteric IKK-β kinase inhibitors: Optimization into in vivo active anti-inflammatory agents.

Elkamhawy A, Kim NY, Hassan AHE, Park JE, Paik S, Yang JE, Oh KS, Lee BH, Lee MY, Shin KJ, Pae AN, Lee KT, Roh EJ. Elkamhawy A, et al. Among authors: paik s. Eur J Med Chem. 2020 Feb 15;188:111955. doi: 10.1016/j.ejmech.2019.111955. Epub 2019 Dec 7. Eur J Med Chem. 2020. PMID: 31893550

9

Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B.

Elkamhawy A, Paik S, Kim HJ, Park JH, Londhe AM, Lee K, Pae AN, Park KD, Roh EJ. Elkamhawy A, et al. Among authors: paik s. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1568-1580. doi: 10.1080/14756366.2020.1800666. J Enzyme Inhib Med Chem. 2020. PMID: 32752896 Free PMC article.

10

Discovery of novel and potent safinamide-based derivatives as highly selective hMAO-B inhibitors for treatment of Parkinson's disease (PD): Design, synthesis, in vitro, in vivo and in silico biological studies.

Elkamhawy A, Paik S, Park JH, Kim HJ, Hassan AHE, Lee K, Park KD, Roh EJ. Elkamhawy A, et al. Among authors: paik s. Bioorg Chem. 2021 Oct;115:105233. doi: 10.1016/j.bioorg.2021.105233. Epub 2021 Aug 2. Bioorg Chem. 2021. PMID: 34390968

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