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Small structural changes of the imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitors produce an improved safety profile.
Futatsugi K, Huard K, Kung DW, Pettersen JC, Flynn DA, Gosset JR, Aspnes GE, Barnes RJ, Cabral S, Dowling MS, Fernando DP, Goosen TC, Gorczyca WP, Hepworth D, Herr M, Lavergne S, Li Q, Niosi M, Orr STM, Pardo ID, Perez SM, Purkal J, Schmahai TJ, Shirai N, Shoieb AM, Zhou J, Goodwin B. Futatsugi K, et al. Among authors: pardo id. Medchemcomm. 2016 Nov 22;8(4):771-779. doi: 10.1039/c6md00564k. eCollection 2017 Apr 1. Medchemcomm. 2016. PMID: 30108796 Free PMC article.
STP Position Paper: Recommended Best Practices for Sampling, Processing, and Analysis of the Peripheral Nervous System (Nerves and Somatic and Autonomic Ganglia) during Nonclinical Toxicity Studies.
Bolon B, Krinke G, Butt MT, Rao DB, Pardo ID, Jortner BS, Garman RH, Jensen K, Andrews-Jones L, Morrison JP, Sharma AK, Thibodeau MS. Bolon B, et al. Among authors: pardo id. Toxicol Pathol. 2018 Jun;46(4):372-402. doi: 10.1177/0192623318772484. Epub 2018 May 22. Toxicol Pathol. 2018. PMID: 29787347
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