Baasov T - Search Results

1

Exploring eukaryotic versus prokaryotic ribosomal RNA recognition with aminoglycoside derivatives.

Sabbavarapu NM, Pieńko T, Zalman BH, Trylska J, Baasov T. Sabbavarapu NM, et al. Among authors: baasov t. Medchemcomm. 2018 Feb 2;9(3):503-508. doi: 10.1039/c8md00001h. eCollection 2018 Mar 1. Medchemcomm. 2018. PMID: 30108940 Free PMC article.

2

When Proteins Start to Make Sense: Fine-tuning Aminoglycosides for PTC Suppression Therapy.

Shalev M, Baasov T. Shalev M, et al. Among authors: baasov t. Medchemcomm. 2014 Aug 1;5(8):1092-1105. doi: 10.1039/C4MD00081A. Medchemcomm. 2014. PMID: 25147726 Free PMC article.

3

Design of Novel Aminoglycoside Derivatives with Enhanced Suppression of Diseases-Causing Nonsense Mutations.

Sabbavarapu NM, Shavit M, Degani Y, Smolkin B, Belakhov V, Baasov T. Sabbavarapu NM, et al. Among authors: baasov t. ACS Med Chem Lett. 2016 Feb 8;7(4):418-23. doi: 10.1021/acsmedchemlett.6b00006. eCollection 2016 Apr 14. ACS Med Chem Lett. 2016. PMID: 27096052 Free PMC article.

4

Towards Catalytic Antibiotics: Redesign of Aminoglycosides To Catalytically Disable Bacterial Ribosomes.

Smolkin B, Khononov A, Pieńko T, Shavit M, Belakhov V, Trylska J, Baasov T. Smolkin B, et al. Among authors: baasov t. Chembiochem. 2019 Jan 18;20(2):247-259. doi: 10.1002/cbic.201800549. Epub 2018 Dec 21. Chembiochem. 2019. PMID: 30474295

5

Dynamic Intramolecular Cap for Preserving Metallodrug Integrity─A Case of Catalytic Fluoroquinolones.

Goldmeier MN, Khononov A, Belakhov V, Pieńko T, Orbach N, Gilad Barzilay Y, Baasov T. Goldmeier MN, et al. Among authors: baasov t. J Med Chem. 2022 Oct 27;65(20):14049-14065. doi: 10.1021/acs.jmedchem.2c01302. Epub 2022 Oct 11. J Med Chem. 2022. PMID: 36219830 Free PMC article.

6

Balancing Nonsense Mutation Readthrough and Toxicity of Designer Aminoglycosides for Treatment of Genetic Diseases.

Guchhait S, Khononov A, Pieńko T, Belakhov V, Baasov T. Guchhait S, et al. Among authors: baasov t. ACS Med Chem Lett. 2023 Apr 27;14(6):794-801. doi: 10.1021/acsmedchemlett.3c00089. eCollection 2023 Jun 8. ACS Med Chem Lett. 2023. PMID: 37312846 Free PMC article.

7

Design, synthesis, and evaluation of novel fluoroquinolone-aminoglycoside hybrid antibiotics.

Pokrovskaya V, Belakhov V, Hainrichson M, Yaron S, Baasov T. Pokrovskaya V, et al. Among authors: baasov t. J Med Chem. 2009 Apr 23;52(8):2243-54. doi: 10.1021/jm900028n. J Med Chem. 2009. PMID: 19301822

8

Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations.

Nudelman I, Rebibo-Sabbah A, Cherniavsky M, Belakhov V, Hainrichson M, Chen F, Schacht J, Pilch DS, Ben-Yosef T, Baasov T. Nudelman I, et al. Among authors: baasov t. J Med Chem. 2009 May 14;52(9):2836-45. doi: 10.1021/jm801640k. J Med Chem. 2009. PMID: 19309154 Free PMC article.

9

Identification of the molecular attributes required for aminoglycoside activity against Leishmania.

Shalev M, Kondo J, Kopelyanskiy D, Jaffe CL, Adir N, Baasov T. Shalev M, et al. Among authors: baasov t. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13333-8. doi: 10.1073/pnas.1307365110. Epub 2013 Jul 29. Proc Natl Acad Sci U S A. 2013. PMID: 23898171 Free PMC article.

10

Redesign of aminoglycosides for treatment of human genetic diseases caused by premature stop mutations.

Nudelman I, Rebibo-Sabbah A, Shallom-Shezifi D, Hainrichson M, Stahl I, Ben-Yosef T, Baasov T. Nudelman I, et al. Among authors: baasov t. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6310-5. doi: 10.1016/j.bmcl.2006.09.013. Epub 2006 Sep 25. Bioorg Med Chem Lett. 2006. PMID: 16997553

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