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Page 1
Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.
Schnute ME, Wennerstål M, Alley J, Bengtsson M, Blinn JR, Bolten CW, Braden T, Bonn T, Carlsson B, Caspers N, Chen M, Choi C, Collis LP, Crouse K, Färnegårdh M, Fennell KF, Fish S, Flick AC, Goos-Nilsson A, Gullberg H, Harris PK, Heasley SE, Hegen M, Hromockyj AE, Hu X, Husman B, Janosik T, Jones P, Kaila N, Kallin E, Kauppi B, Kiefer JR, Knafels J, Koehler K, Kruger L, Kurumbail RG, Kyne RE Jr, Li W, Löfstedt J, Long SA, Menard CA, Mente S, Messing D, Meyers MJ, Napierata L, Nöteberg D, Nuhant P, Pelc MJ, Prinsen MJ, Rhönnstad P, Backström-Rydin E, Sandberg J, Sandström M, Shah F, Sjöberg M, Sundell A, Taylor AP, Thorarensen A, Trujillo JI, Trzupek JD, Unwalla R, Vajdos FF, Weinberg RA, Wood DC, Xing L, Zamaratski E, Zapf CW, Zhao Y, Wilhelmsson A, Berstein G. Schnute ME, et al. Among authors: kyne re jr. J Med Chem. 2018 Dec 13;61(23):10415-10439. doi: 10.1021/acs.jmedchem.8b00392. Epub 2018 Sep 9. J Med Chem. 2018. PMID: 30130103
Correction to Synthetic Approaches to the New Drugs Approved During 2015.
Flick AC, Ding HX, Leverett CA, Kyne RE Jr, Liu KK, Fink SJ, O'Donnell CJ. Flick AC, et al. Among authors: kyne re jr. J Med Chem. 2017 Oct 26;60(20):8680. doi: 10.1021/acs.jmedchem.7b01452. Epub 2017 Oct 16. J Med Chem. 2017. PMID: 29035530 No abstract available.
Synthetic Approaches to the New Drugs Approved During 2015.
Flick AC, Ding HX, Leverett CA, Kyne RE Jr, Liu KK, Fink SJ, O'Donnell CJ. Flick AC, et al. Among authors: kyne re jr. J Med Chem. 2017 Aug 10;60(15):6480-6515. doi: 10.1021/acs.jmedchem.7b00010. Epub 2017 May 3. J Med Chem. 2017. PMID: 28421763 Review.
Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).
Gopalsamy A, Narayanan A, Liu S, Parikh MD, Kyne RE Jr, Fadeyi O, Tones MA, Cherry JJ, Nabhan JF, LaRosa G, Petersen DN, Menard C, Foley TL, Noell S, Ren Y, Loria PM, Maglich-Goodwin J, Rong H, Jones LH. Gopalsamy A, et al. Among authors: kyne re jr. J Med Chem. 2017 Apr 13;60(7):3094-3108. doi: 10.1021/acs.jmedchem.7b00124. Epub 2017 Mar 16. J Med Chem. 2017. PMID: 28257199
Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis.
Fadeyi O, Parikh MD, Chen MZ, Kyne RE Jr, Taylor AP, O'Doherty I, Kaiser SE, Barbas S, Niessen S, Shi M, Weinrich SL, Kath JC, Jones LH, Robinson RP. Fadeyi O, et al. Among authors: kyne re jr. Chembiochem. 2016 Oct 17;17(20):1925-1930. doi: 10.1002/cbic.201600427. Epub 2016 Aug 30. Chembiochem. 2016. PMID: 27504718
Synthetic approaches to the 2014 new drugs.
Flick AC, Ding HX, Leverett CA, Kyne RE Jr, Liu KK, Fink SJ, O'Donnell CJ. Flick AC, et al. Among authors: kyne re jr. Bioorg Med Chem. 2016 May 1;24(9):1937-80. doi: 10.1016/j.bmc.2016.03.004. Epub 2016 Mar 9. Bioorg Med Chem. 2016. PMID: 27020685 Review.
Synthetic approaches to the 2013 new drugs.
Ding HX, Leverett CA, Kyne RE Jr, Liu KK, Fink SJ, Flick AC, O'Donnell CJ. Ding HX, et al. Among authors: kyne re jr. Bioorg Med Chem. 2015 May 1;23(9):1895-922. doi: 10.1016/j.bmc.2015.02.056. Epub 2015 Mar 6. Bioorg Med Chem. 2015. PMID: 25797159 Review.
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