Wingler LM - Search Results

1

G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β₂-adrenergic receptor.

Choi M, Staus DP, Wingler LM, Ahn S, Pani B, Capel WD, Lefkowitz RJ. Choi M, et al. Among authors: wingler lm. Sci Signal. 2018 Aug 21;11(544):eaar7084. doi: 10.1126/scisignal.aar7084. Sci Signal. 2018. PMID: 30131371

2

Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.

Staus DP, Wingler LM, Strachan RT, Rasmussen SG, Pardon E, Ahn S, Steyaert J, Kobilka BK, Lefkowitz RJ. Staus DP, et al. Among authors: wingler lm. Mol Pharmacol. 2014 Mar;85(3):472-81. doi: 10.1124/mol.113.089516. Epub 2013 Dec 6. Mol Pharmacol. 2014. PMID: 24319111 Free PMC article.

3

Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling.

Staus DP, Wingler LM, Choi M, Pani B, Manglik A, Kruse AC, Lefkowitz RJ. Staus DP, et al. Among authors: wingler lm. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3834-3839. doi: 10.1073/pnas.1722336115. Epub 2018 Mar 26. Proc Natl Acad Sci U S A. 2018. PMID: 29581292 Free PMC article.

4

Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations.

Wingler LM, Elgeti M, Hilger D, Latorraca NR, Lerch MT, Staus DP, Dror RO, Kobilka BK, Hubbell WL, Lefkowitz RJ. Wingler LM, et al. Cell. 2019 Jan 24;176(3):468-478.e11. doi: 10.1016/j.cell.2018.12.005. Epub 2019 Jan 10. Cell. 2019. PMID: 30639099 Free PMC article.

5

Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody.

Wingler LM, McMahon C, Staus DP, Lefkowitz RJ, Kruse AC. Wingler LM, et al. Cell. 2019 Jan 24;176(3):479-490.e12. doi: 10.1016/j.cell.2018.12.006. Epub 2019 Jan 10. Cell. 2019. PMID: 30639100 Free PMC article.

6

Detergent- and phospholipid-based reconstitution systems have differential effects on constitutive activity of G-protein-coupled receptors.

Staus DP, Wingler LM, Pichugin D, Prosser RS, Lefkowitz RJ. Staus DP, et al. Among authors: wingler lm. J Biol Chem. 2019 Sep 6;294(36):13218-13223. doi: 10.1074/jbc.AC119.009848. Epub 2019 Jul 30. J Biol Chem. 2019. PMID: 31362983 Free PMC article.

7

Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc.

Staus DP, Hu H, Robertson MJ, Kleinhenz ALW, Wingler LM, Capel WD, Latorraca NR, Lefkowitz RJ, Skiniotis G. Staus DP, et al. Among authors: wingler lm. Nature. 2020 Mar;579(7798):297-302. doi: 10.1038/s41586-020-1954-0. Epub 2020 Jan 16. Nature. 2020. PMID: 31945772 Free PMC article.

8

Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor.

Suomivuori CM, Latorraca NR, Wingler LM, Eismann S, King MC, Kleinhenz ALW, Skiba MA, Staus DP, Kruse AC, Lefkowitz RJ, Dror RO. Suomivuori CM, et al. Among authors: wingler lm. Science. 2020 Feb 21;367(6480):881-887. doi: 10.1126/science.aaz0326. Science. 2020. PMID: 32079767 Free PMC article.

9

Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR.

Wingler LM, Skiba MA, McMahon C, Staus DP, Kleinhenz ALW, Suomivuori CM, Latorraca NR, Dror RO, Lefkowitz RJ, Kruse AC. Wingler LM, et al. Science. 2020 Feb 21;367(6480):888-892. doi: 10.1126/science.aay9813. Science. 2020. PMID: 32079768 Free PMC article.

10

Conformational Basis of G Protein-Coupled Receptor Signaling Versatility.

Wingler LM, Lefkowitz RJ. Wingler LM, et al. Trends Cell Biol. 2020 Sep;30(9):736-747. doi: 10.1016/j.tcb.2020.06.002. Epub 2020 Jul 2. Trends Cell Biol. 2020. PMID: 32622699 Free PMC article. Review.

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