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Page 1
A mouse model of pseudohypoaldosteronism type II reveals a novel mechanism of renal tubular acidosis.
López-Cayuqueo KI, Chavez-Canales M, Pillot A, Houillier P, Jayat M, Baraka-Vidot J, Trepiccione F, Baudrie V, Büsst C, Soukaseum C, Kumai Y, Jeunemaître X, Hadchouel J, Eladari D, Chambrey R. López-Cayuqueo KI, et al. Among authors: soukaseum c. Kidney Int. 2018 Sep;94(3):514-523. doi: 10.1016/j.kint.2018.05.001. Epub 2018 Jul 7. Kidney Int. 2018. PMID: 30146013 Free article.
Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension.
Hadchouel J, Soukaseum C, Büsst C, Zhou XO, Baudrie V, Zürrer T, Cambillau M, Elghozi JL, Lifton RP, Loffing J, Jeunemaitre X. Hadchouel J, et al. Among authors: soukaseum c. Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18109-14. doi: 10.1073/pnas.1006128107. Epub 2010 Oct 4. Proc Natl Acad Sci U S A. 2010. PMID: 20921400 Free PMC article.
WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron.
Vidal-Petiot E, Elvira-Matelot E, Mutig K, Soukaseum C, Baudrie V, Wu S, Cheval L, Huc E, Cambillau M, Bachmann S, Doucet A, Jeunemaitre X, Hadchouel J. Vidal-Petiot E, et al. Among authors: soukaseum c. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14366-71. doi: 10.1073/pnas.1304230110. Epub 2013 Aug 12. Proc Natl Acad Sci U S A. 2013. PMID: 23940364 Free PMC article.
Acute genetic ablation of pendrin lowers blood pressure in mice.
Trepiccione F, Soukaseum C, Baudrie V, Kumai Y, Teulon J, Villoutreix B, Cornière N, Wangemann P, Griffith AJ, Byung Choi Y, Hadchouel J, Chambrey R, Eladari D. Trepiccione F, et al. Among authors: soukaseum c. Nephrol Dial Transplant. 2017 Jul 1;32(7):1137-1145. doi: 10.1093/ndt/gfw393. Nephrol Dial Transplant. 2017. PMID: 28064162 Free PMC article.
KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron.
Louis-Dit-Picard H, Barc J, Trujillano D, Miserey-Lenkei S, Bouatia-Naji N, Pylypenko O, Beaurain G, Bonnefond A, Sand O, Simian C, Vidal-Petiot E, Soukaseum C, Mandet C, Broux F, Chabre O, Delahousse M, Esnault V, Fiquet B, Houillier P, Bagnis CI, Koenig J, Konrad M, Landais P, Mourani C, Niaudet P, Probst V, Thauvin C, Unwin RJ, Soroka SD, Ehret G, Ossowski S, Caulfield M; International Consortium for Blood Pressure (ICBP); Bruneval P, Estivill X, Froguel P, Hadchouel J, Schott JJ, Jeunemaitre X. Louis-Dit-Picard H, et al. Among authors: soukaseum c. Nat Genet. 2012 Mar 11;44(4):456-60, S1-3. doi: 10.1038/ng.2218. Nat Genet. 2012. PMID: 22406640
WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.
Chávez-Canales M, Zhang C, Soukaseum C, Moreno E, Pacheco-Alvarez D, Vidal-Petiot E, Castañeda-Bueno M, Vázquez N, Rojas-Vega L, Meermeier NP, Rogers S, Jeunemaitre X, Yang CL, Ellison DH, Gamba G, Hadchouel J. Chávez-Canales M, et al. Among authors: soukaseum c. Hypertension. 2014 Nov;64(5):1047-53. doi: 10.1161/HYPERTENSIONAHA.114.04036. Epub 2014 Aug 11. Hypertension. 2014. PMID: 25113964 Free PMC article.
A fate-mapping approach reveals the composite origin of the connecting tubule and alerts on "single-cell"-specific KO model of the distal nephron.
Trepiccione F, Soukaseum C, Iervolino A, Petrillo F, Zacchia M, Schutz G, Eladari D, Capasso G, Hadchouel J. Trepiccione F, et al. Among authors: soukaseum c. Am J Physiol Renal Physiol. 2016 Nov 1;311(5):F901-F906. doi: 10.1152/ajprenal.00286.2016. Epub 2016 Aug 31. Am J Physiol Renal Physiol. 2016. PMID: 27582101 Free article.
LIM kinase/cofilin dysregulation promotes macrothrombocytopenia in severe von Willebrand disease-type 2B.
Kauskot A, Poirault-Chassac S, Adam F, Muczynski V, Aymé G, Casari C, Bordet JC, Soukaseum C, Rothschild C, Proulle V, Pietrzyk-Nivau A, Berrou E, Christophe OD, Rosa JP, Lenting PJ, Bryckaert M, Denis CV, Baruch D. Kauskot A, et al. Among authors: soukaseum c. JCI Insight. 2016 Oct 6;1(16):e88643. doi: 10.1172/jci.insight.88643. JCI Insight. 2016. PMID: 27734030 Free PMC article.
16 results