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Author Correction: Prospective de novo drug design with deep interactome learning.
Atz K, Cotos L, Isert C, Håkansson M, Focht D, Hilleke M, Nippa DF, Iff M, Ledergerber J, Schiebroek CCG, Romeo V, Hiss JA, Merk D, Schneider P, Kuhn B, Grether U, Schneider G. Atz K, et al. Among authors: merk d. Nat Commun. 2025 Jan 17;16(1):783. doi: 10.1038/s41467-025-55964-1. Nat Commun. 2025. PMID: 39824793 No abstract available.
Genome-wide CRISPR-Cas 9 screens identify BCL family members as modulators of response to regorafenib in experimental glioma.
Haeusser LA, Becker H, Kuhlburger L, Zago M, Walter B, Tsiami F, Erdmann S, Trampert J, Surender S, Stahl A, Templin M, Wegner E, Schmidt T, Schmees C, Casadei N, Sevenich L, Claassen M, Nahnsen S, Beck S, Merk DJ, Tabatabai G. Haeusser LA, et al. Among authors: merk dj. Neuro Oncol. 2025 Jan 4:noae278. doi: 10.1093/neuonc/noae278. Online ahead of print. Neuro Oncol. 2025. PMID: 39756423
Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open.
Tredup C, Ackloo S, Beck H, Brown PJ, Bullock AN, Ciulli A, Dikic I, Edfeldt K, Edwards AM, Elkins JM, Farin HF, Fon EA, Gstaiger M, Günther J, Gustavsson AL, Häberle S, Isigkeit L, Huber KVM, Kotschy A, Krämer O, Leach AR, Marsden BD, Matsui H, Merk D, Montel F, Mulder MPC, Müller S, Owen DR, Proschak E, Röhm S, Stolz A, Sundström M, von Delft F, Willson TM, Arrowsmith CH, Knapp S. Tredup C, et al. Among authors: merk d. RSC Med Chem. 2024 Nov 29. doi: 10.1039/d4md00735b. Online ahead of print. RSC Med Chem. 2024. PMID: 39618964 Free PMC article.
Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors.
Merk DJ, Tsiami F, Hirsch S, Walter B, Haeusser LA, Maile JD, Stahl A, Jarboui MA, Lechado-Terradas A, Klose F, Babaei S, Admard J, Casadei N, Roggia C, Spohn M, Schittenhelm J, Singer S, Schüller U, Piccioni F, Persky NS, Claassen M, Tatagiba M, Kahle PJ, Root DE, Templin M, Tabatabai G. Merk DJ, et al. Genome Biol. 2024 Dec 2;25(1):301. doi: 10.1186/s13059-024-03438-w. Genome Biol. 2024. PMID: 39617889 Free PMC article.
We are MedChem: The Frontiers in Medicinal Chemistry 2024.
Schiedel M, Barbie P, Pape F, Pinto M, Unzue Lopez A, Méndez M, Hessler G, Merk D, Gehringer M, Lamers C. Schiedel M, et al. Among authors: merk d. ChemMedChem. 2024 Dec 2;19(23):e202400543. doi: 10.1002/cmdc.202400543. Epub 2024 Sep 23. ChemMedChem. 2024. PMID: 39308157
Automated design of multi-target ligands by generative deep learning.
Isigkeit L, Hörmann T, Schallmayer E, Scholz K, Lillich FF, Ehrler JHM, Hufnagel B, Büchner J, Marschner JA, Pabel J, Proschak E, Merk D. Isigkeit L, et al. Among authors: merk d. Nat Commun. 2024 Sep 11;15(1):7946. doi: 10.1038/s41467-024-52060-8. Nat Commun. 2024. PMID: 39261471 Free PMC article.
Tuning RXR Modulators for PGC1α Recruitment.
Nawa F, Sai M, Vietor J, Schwarzenbach R, Bitić A, Wolff S, Ildefeld N, Pabel J, Wein T, Marschner JA, Heering J, Merk D. Nawa F, et al. Among authors: merk d. J Med Chem. 2024 Sep 26;67(18):16338-16354. doi: 10.1021/acs.jmedchem.4c01231. Epub 2024 Sep 11. J Med Chem. 2024. PMID: 39258574
195 results