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Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models.
Weihofen A, Liu Y, Arndt JW, Huy C, Quan C, Smith BA, Baeriswyl JL, Cavegn N, Senn L, Su L, Marsh G, Auluck PK, Montrasio F, Nitsch RM, Hirst WD, Cedarbaum JM, Pepinsky RB, Grimm J, Weinreb PH. Weihofen A, et al. Neurobiol Dis. 2019 Apr;124:276-288. doi: 10.1016/j.nbd.2018.10.016. Epub 2018 Oct 28. Neurobiol Dis. 2019. PMID: 30381260 Free article.
Characterization of tau binding by gosuranemab.
Sopko R, Golonzhka O, Arndt J, Quan C, Czerkowicz J, Cameron A, Smith B, Murugesan Y, Gibbons G, Kim SJ, Trojanowski JQ, Lee VMY, Brunden KR, Graham DL, Weinreb PH, Hering H. Sopko R, et al. Among authors: smith b. Neurobiol Dis. 2020 Dec;146:105120. doi: 10.1016/j.nbd.2020.105120. Epub 2020 Sep 28. Neurobiol Dis. 2020. PMID: 32991997 Free article.
MOG autoantibodies trigger a tightly-controlled FcR and BTK-driven microglia proliferative response.
Pellerin K, Rubino SJ, Burns JC, Smith BA, McCarl CA, Zhu J, Jandreski L, Cullen P, Carlile TM, Li A, Rebollar JV, Sybulski J, Reynolds TL, Zhang B, Basile R, Tang H, Harp CP, Pellerin A, Silbereis J, Franchimont N, Cahir-McFarland E, Ransohoff RM, Cameron TO, Mingueneau M. Pellerin K, et al. Among authors: smith ba. Brain. 2021 Sep 4;144(8):2361-2374. doi: 10.1093/brain/awab231. Brain. 2021. PMID: 34145876
Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model.
Nguyen L, Montrasio F, Pattamatta A, Tusi SK, Bardhi O, Meyer KD, Hayes L, Nakamura K, Banez-Coronel M, Coyne A, Guo S, Laboissonniere LA, Gu Y, Narayanan S, Smith B, Nitsch RM, Kankel MW, Rushe M, Rothstein J, Zu T, Grimm J, Ranum LPW. Nguyen L, et al. Among authors: smith b. Neuron. 2020 Feb 19;105(4):645-662.e11. doi: 10.1016/j.neuron.2019.11.007. Epub 2019 Dec 9. Neuron. 2020. PMID: 31831332 Free PMC article.
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