Hymel D - Search Results

1

Histidine N(τ)-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors.

Hymel D, Grant RA, Tsuji K, Yaffe MB, Burke TR Jr. Hymel D, et al. Bioorg Med Chem Lett. 2018 Oct 15;28(19):3202-3205. doi: 10.1016/j.bmcl.2018.08.018. Epub 2018 Aug 19. Bioorg Med Chem Lett. 2018. PMID: 30174151 Free PMC article.

2

Application of oxime-diversification to optimize ligand interactions within a cryptic pocket of the polo-like kinase 1 polo-box domain.

Zhao XZ, Hymel D, Burke TR Jr. Zhao XZ, et al. Among authors: hymel d. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5009-5012. doi: 10.1016/j.bmcl.2016.08.098. Epub 2016 Sep 2. Bioorg Med Chem Lett. 2016. PMID: 27624074 Free PMC article.

3

Phosphatase-Stable Phosphoamino Acid Mimetics That Enhance Binding Affinities with the Polo-Box Domain of Polo-like Kinase 1.

Hymel D, Burke TR Jr. Hymel D, et al. ChemMedChem. 2017 Feb 3;12(3):202-206. doi: 10.1002/cmdc.201600574. Epub 2017 Jan 9. ChemMedChem. 2017. PMID: 27992122 Free PMC article.

4

Enhancing polo-like kinase 1 selectivity of polo-box domain-binding peptides.

Zhao XZ, Hymel D, Burke TR Jr. Zhao XZ, et al. Among authors: hymel d. Bioorg Med Chem. 2017 Oct 1;25(19):5041-5049. doi: 10.1016/j.bmc.2017.02.063. Epub 2017 Feb 28. Bioorg Med Chem. 2017. PMID: 28285924 Free PMC article.

5

Development of Highly Selective 1,2,3-Triazole-containing Peptidic Polo-like Kinase 1 Polo-box Domain-binding Inhibitors.

Zhao XZ, Tsuji K, Hymel D, Burke TR Jr. Zhao XZ, et al. Among authors: hymel d. Molecules. 2019 Apr 16;24(8):1488. doi: 10.3390/molecules24081488. Molecules. 2019. PMID: 31014020 Free PMC article.

6

A new genre of fluorescence recovery assay to evaluate polo-like kinase 1 ATP-competitive inhibitors.

Tsuji K, Hymel D, Burke TR. Tsuji K, et al. Among authors: hymel d. Anal Methods. 2020 Sep 28;12(36):4418-4421. doi: 10.1039/d0ay01223h. Epub 2020 Sep 3. Anal Methods. 2020. PMID: 32970049 Free PMC article.

7

Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain - binding peptide macrocycles.

Hymel D, Tsuji K, Grant RA, Chingle RM, Kunciw DL, Yaffe MB, Burke TR Jr. Hymel D, et al. Org Biomol Chem. 2021 Sep 22;19(36):7843-7854. doi: 10.1039/d1ob01120k. Org Biomol Chem. 2021. PMID: 34346472 Free PMC article.

8

Current progress and future perspectives in the development of anti-polo-like kinase 1 therapeutic agents.

Park JE, Hymel D, Burke TR Jr, Lee KS. Park JE, et al. Among authors: hymel d. F1000Res. 2017 Jun 29;6:1024. doi: 10.12688/f1000research.11398.1. eCollection 2017. F1000Res. 2017. PMID: 28721210 Free PMC article. Review.

9

Development of ultra-high affinity bivalent ligands targeting the polo-like kinase 1.

Tsuji K, Hymel D, Ma B, Tamamura H, Nussinov R, Burke TR Jr. Tsuji K, et al. Among authors: hymel d. RSC Chem Biol. 2022 Jul 15;3(9):1111-1120. doi: 10.1039/d2cb00153e. eCollection 2022 Aug 31. RSC Chem Biol. 2022. PMID: 36128509 Free PMC article.

10

Corrigendum: Phosphatase-Stable Phosphoamino Acid Mimetics That Enhance Binding Affinities with the Polo-Box Domain of Polo-like Kinase 1.

Hymel D, Burke TR Jr. Hymel D, et al. ChemMedChem. 2017 Feb 3;12(3):278. doi: 10.1002/cmdc.201700019. Epub 2017 Jan 23. ChemMedChem. 2017. PMID: 28185436 Free PMC article. No abstract available.

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