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Page 1
Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer.
Lenos KJ, Miedema DM, Lodestijn SC, Nijman LE, van den Bosch T, Romero Ros X, Lourenço FC, Lecca MC, van der Heijden M, van Neerven SM, van Oort A, Leveille N, Adam RS, de Sousa E Melo F, Otten J, Veerman P, Hypolite G, Koens L, Lyons SK, Stassi G, Winton DJ, Medema JP, Morrissey E, Bijlsma MF, Vermeulen L. Lenos KJ, et al. Among authors: hypolite g. Nat Cell Biol. 2018 Oct;20(10):1193-1202. doi: 10.1038/s41556-018-0179-z. Epub 2018 Sep 3. Nat Cell Biol. 2018. PMID: 30177776 Free PMC article.
Blueprint of human thymopoiesis reveals molecular mechanisms of stage-specific TCR enhancer activation.
Cieslak A, Charbonnier G, Tesio M, Mathieu EL, Belhocine M, Touzart A, Smith C, Hypolite G, Andrieu GP, Martens JHA, Janssen-Megens E, Gut M, Gut I, Boissel N, Petit A, Puthier D, Macintyre E, Stunnenberg HG, Spicuglia S, Asnafi V. Cieslak A, et al. Among authors: hypolite g. J Exp Med. 2020 Sep 7;217(9):e20192360. doi: 10.1084/jem.20192360. J Exp Med. 2020. PMID: 32667968 Free PMC article.
A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis.
Bond J, Krzywon A, Lhermitte L, Roumier C, Roggy A, Belhocine M, Kheirallah AA, Villarese P, Hypolite G, Garnache-Ottou F, Castaigne S, Boissel N, Asnafi V, Preudhomme C, Dombret H, Laurenti E, Macintyre E. Bond J, et al. Among authors: hypolite g. Leukemia. 2021 Mar;35(3):724-736. doi: 10.1038/s41375-020-0965-z. Epub 2020 Jul 13. Leukemia. 2021. PMID: 32655144 Free PMC article.
CBFβ-SMMHC regulates ribosomal gene transcription and alters ribosome biogenesis.
Cordonnier G, Mandoli A, Radhouane A, Hypolite G, Lhermitte L, Belhocine M, Asnafi V, Macintyre E, Martens JHA, Fumagalli S, Bond J. Cordonnier G, et al. Among authors: hypolite g. Leukemia. 2017 Jun;31(6):1443-1446. doi: 10.1038/leu.2017.53. Epub 2017 Feb 15. Leukemia. 2017. PMID: 28196984 No abstract available.
ATP citrate lyase is an essential player in the metabolic rewiring induced by PTEN loss during T-ALL development.
Andrieu GP, Hypolite G, Latiri M, Balducci E, Costa C, Verhoeyen E, Courgeon M, Allatif O, Nemazanyy I, Panasyuk G, Wellen KE, Herranz D, Genestier L, Macintyre EA, Asnafi V, Tesio M. Andrieu GP, et al. Among authors: hypolite g. Blood Adv. 2024 Nov 15:bloodadvances.2024013762. doi: 10.1182/bloodadvances.2024013762. Online ahead of print. Blood Adv. 2024. PMID: 39546747
Harnessing the MYB-dependent TAL1 5'super-enhancer for targeted therapy in T-ALL.
Smith C, Touzart A, Simonin M, Tran-Quang C, Hypolite G, Latiri M, Andrieu GP, Balducci E, Dourthe MÉ, Goyal A, Huguet F, Petit A, Ifrah N, Baruchel A, Dombret H, Macintyre E, Plass C, Ghysdael J, Boissel N, Asnafi V. Smith C, et al. Among authors: hypolite g. Mol Cancer. 2023 Jan 18;22(1):12. doi: 10.1186/s12943-022-01701-x. Mol Cancer. 2023. PMID: 36650499 Free PMC article.
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