O'Doherty UT - Search Results

1

HLA-C downregulation by HIV-1 adapts to host HLA genotype.

Bachtel ND, Umviligihozo G, Pickering S, Mota TM, Liang H, Del Prete GQ, Chatterjee P, Lee GQ, Thomas R, Brockman MA, Neil S, Carrington M, Bwana B, Bangsberg DR, Martin JN, Kallas EG, Donini CS, Cerqueira NB, O'Doherty UT, Hahn BH, Jones RB, Brumme ZL, Nixon DF, Apps R. Bachtel ND, et al. Among authors: o doherty ut. PLoS Pathog. 2018 Sep 4;14(9):e1007257. doi: 10.1371/journal.ppat.1007257. eCollection 2018 Sep. PLoS Pathog. 2018. PMID: 30180214 Free PMC article.

2

Elite suppressors harbor low levels of integrated HIV DNA and high levels of 2-LTR circular HIV DNA compared to HIV+ patients on and off HAART.

Graf EH, Mexas AM, Yu JJ, Shaheen F, Liszewski MK, Di Mascio M, Migueles SA, Connors M, O'Doherty U. Graf EH, et al. PLoS Pathog. 2011 Feb;7(2):e1001300. doi: 10.1371/journal.ppat.1001300. Epub 2011 Feb 24. PLoS Pathog. 2011. PMID: 21383972 Free PMC article.

3

Directly infected resting CD4+T cells can produce HIV Gag without spreading infection in a model of HIV latency.

Pace MJ, Graf EH, Agosto LM, Mexas AM, Male F, Brady T, Bushman FD, O'Doherty U. Pace MJ, et al. PLoS Pathog. 2012;8(7):e1002818. doi: 10.1371/journal.ppat.1002818. Epub 2012 Jul 26. PLoS Pathog. 2012. PMID: 22911005 Free PMC article.

4

Gag-positive reservoir cells are susceptible to HIV-specific cytotoxic T lymphocyte mediated clearance in vitro and can be detected in vivo [corrected].

Graf EH, Pace MJ, Peterson BA, Lynch LJ, Chukwulebe SB, Mexas AM, Shaheen F, Martin JN, Deeks SG, Connors M, Migueles SA, O'Doherty U. Graf EH, et al. PLoS One. 2013 Aug 7;8(8):e71879. doi: 10.1371/journal.pone.0071879. eCollection 2013. PLoS One. 2013. PMID: 23951263 Free PMC article.

5

Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers.

Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, Shacklett BL, Wong JK, Deeks SG. Hatano H, et al. PLoS Pathog. 2013;9(10):e1003691. doi: 10.1371/journal.ppat.1003691. Epub 2013 Oct 10. PLoS Pathog. 2013. PMID: 24130489 Free PMC article. Clinical Trial.

6

Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion.

Pinzone MR, VanBelzen DJ, Weissman S, Bertuccio MP, Cannon L, Venanzi-Rullo E, Migueles S, Jones RB, Mota T, Joseph SB, Groen K, Pasternak AO, Hwang WT, Sherman B, Vourekas A, Nunnari G, O'Doherty U. Pinzone MR, et al. Nat Commun. 2019 Feb 13;10(1):728. doi: 10.1038/s41467-019-08431-7. Nat Commun. 2019. PMID: 30760706 Free PMC article.

7

Current HIV/SIV Reservoir Assays for Preclinical and Clinical Applications: Recommendations from the Experts 2022 NIAID Workshop Summary.

Sanders-Beer BE, Archin NM, Brumme ZL, Busch MP, Deleage C, O'Doherty U, Hughes SH, Jerome KR, Jones RB, Karn J, Kearney MF, Keele BF, Kulpa DA, Laird GM, Li JZ, Lichterfeld MD, Nussenzweig MC, Persaud D, Yukl SA, Siliciano RF, Mellors JW. Sanders-Beer BE, et al. AIDS Res Hum Retroviruses. 2023 Jun 19. doi: 10.1089/AID.2022.0188. Online ahead of print. AIDS Res Hum Retroviruses. 2023. PMID: 37126090

8

Human immunodeficiency virus type 1 can establish latent infection in resting CD4+ T cells in the absence of activating stimuli.

Swiggard WJ, Baytop C, Yu JJ, Dai J, Li C, Schretzenmair R, Theodosopoulos T, O'Doherty U. Swiggard WJ, et al. J Virol. 2005 Nov;79(22):14179-88. doi: 10.1128/JVI.79.22.14179-14188.2005. J Virol. 2005. PMID: 16254353 Free PMC article.

9

HIV-1 integrates into resting CD4+ T cells even at low inoculums as demonstrated with an improved assay for HIV-1 integration.

Agosto LM, Yu JJ, Dai J, Kaletsky R, Monie D, O'Doherty U. Agosto LM, et al. Virology. 2007 Nov 10;368(1):60-72. doi: 10.1016/j.virol.2007.06.001. Epub 2007 Jul 13. Virology. 2007. PMID: 17631931 Free PMC article.

10

HIV integration site distributions in resting and activated CD4+ T cells infected in culture.

Brady T, Agosto LM, Malani N, Berry CC, O'Doherty U, Bushman F. Brady T, et al. AIDS. 2009 Jul 31;23(12):1461-71. doi: 10.1097/QAD.0b013e32832caf28. AIDS. 2009. PMID: 19550285 Free PMC article.

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