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BET bromodomain proteins mediate downstream signaling events following growth factor stimulation in human lung fibroblasts and are involved in bleomycin-induced pulmonary fibrosis.
Tang X, Peng R, Ren Y, Apparsundaram S, Deguzman J, Bauer CM, Hoffman AF, Hamilton S, Liang Z, Zeng H, Fuentes ME, Demartino JA, Kitson C, Stevenson CS, Budd DC. Tang X, et al. Among authors: stevenson cs. Mol Pharmacol. 2013 Jan;83(1):283-93. doi: 10.1124/mol.112.081661. Epub 2012 Oct 31. Mol Pharmacol. 2013. PMID: 23115324
Bleomycin induces molecular changes directly relevant to idiopathic pulmonary fibrosis: a model for "active" disease.
Peng R, Sridhar S, Tyagi G, Phillips JE, Garrido R, Harris P, Burns L, Renteria L, Woods J, Chen L, Allard J, Ravindran P, Bitter H, Liang Z, Hogaboam CM, Kitson C, Budd DC, Fine JS, Bauer CM, Stevenson CS. Peng R, et al. Among authors: stevenson cs. PLoS One. 2013;8(4):e59348. doi: 10.1371/journal.pone.0059348. Epub 2013 Apr 2. PLoS One. 2013. PMID: 23565148 Free PMC article.
Assessment of Brd4 inhibition in idiopathic pulmonary fibrosis lung fibroblasts and in vivo models of lung fibrosis.
Tang X, Peng R, Phillips JE, Deguzman J, Ren Y, Apparsundaram S, Luo Q, Bauer CM, Fuentes ME, DeMartino JA, Tyagi G, Garrido R, Hogaboam CM, Denton CP, Holmes AM, Kitson C, Stevenson CS, Budd DC. Tang X, et al. Among authors: stevenson cs. Am J Pathol. 2013 Aug;183(2):470-9. doi: 10.1016/j.ajpath.2013.04.020. Epub 2013 Jun 10. Am J Pathol. 2013. PMID: 23759512 Free article.
Bleomycin induced lung fibrosis increases work of breathing in the mouse.
Phillips JE, Peng R, Burns L, Harris P, Garrido R, Tyagi G, Fine JS, Stevenson CS. Phillips JE, et al. Among authors: stevenson cs. Pulm Pharmacol Ther. 2012 Aug;25(4):281-5. doi: 10.1016/j.pupt.2011.10.001. Epub 2011 Oct 20. Pulm Pharmacol Ther. 2012. PMID: 22024054
Discovery of highly selective and orally active lysophosphatidic acid receptor-1 antagonists with potent activity on human lung fibroblasts.
Qian Y, Hamilton M, Sidduri A, Gabriel S, Ren Y, Peng R, Kondru R, Narayanan A, Truitt T, Hamid R, Chen Y, Zhang L, Fretland AJ, Sanchez RA, Chang KC, Lucas M, Schoenfeld RC, Laine D, Fuentes ME, Stevenson CS, Budd DC. Qian Y, et al. Among authors: stevenson cs. J Med Chem. 2012 Sep 13;55(17):7920-39. doi: 10.1021/jm301022v. Epub 2012 Aug 29. J Med Chem. 2012. PMID: 22894757
122 results