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Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology.
Zhang C, Seo J, Murakami K, Salem ESB, Bernhard E, Borra VJ, Choi K, Yuan CL, Chan CC, Chen X, Huang T, Weirauch MT, Divanovic S, Qi NR, Thomas HE, Mercer CA, Siomi H, Nakamura T. Zhang C, et al. Among authors: mercer ca. Nat Commun. 2018 Sep 10;9(1):3658. doi: 10.1038/s41467-018-05870-6. Nat Commun. 2018. PMID: 30201950 Free PMC article.
mTOR Kinase Inhibition Effectively Decreases Progression of a Subset of Neuroendocrine Tumors that Progress on Rapalog Therapy and Delays Cardiac Impairment.
Orr-Asman MA, Chu Z, Jiang M, Worley M, LaSance K, Koch SE, Carreira VS, Dahche HM, Plas DR, Komurov K, Qi X, Mercer CA, Anthony LB, Rubinstein J, Thomas HE. Orr-Asman MA, et al. Among authors: mercer ca. Mol Cancer Ther. 2017 Nov;16(11):2432-2441. doi: 10.1158/1535-7163.MCT-17-0058. Epub 2017 Sep 1. Mol Cancer Ther. 2017. PMID: 28864682
mTOR inhibitors synergize on regression, reversal of gene expression, and autophagy in hepatocellular carcinoma.
Thomas HE, Mercer CA, Carnevalli LS, Park J, Andersen JB, Conner EA, Tanaka K, Matsutani T, Iwanami A, Aronow BJ, Manway L, Maira SM, Thorgeirsson SS, Mischel PS, Thomas G, Kozma SC. Thomas HE, et al. Among authors: mercer ca. Sci Transl Med. 2012 Jun 20;4(139):139ra84. doi: 10.1126/scitranslmed.3003923. Epub 2012 Apr 25. Sci Transl Med. 2012. PMID: 22539746 Free PMC article.
mTOR kinase inhibition reduces tissue factor expression and growth of pancreatic neuroendocrine tumors.
Lewis CS, Elnakat Thomas H, Orr-Asman MA, Green LC, Boody RE, Matiash K, Karve A, Hisada YM, Davis HW, Qi X, Mercer CA, Lucas FV, Aronow BJ, Mackman N, Versteeg HH, Bogdanov VY. Lewis CS, et al. Among authors: mercer ca. J Thromb Haemost. 2019 Jan;17(1):169-182. doi: 10.1111/jth.14342. Epub 2018 Dec 25. J Thromb Haemost. 2019. PMID: 30472780 Free PMC article.
A Phase Ib Study of the Dual PI3K/mTOR Inhibitor Dactolisib (BEZ235) Combined with Everolimus in Patients with Advanced Solid Malignancies.
Wise-Draper TM, Moorthy G, Salkeni MA, Karim NA, Thomas HE, Mercer CA, Beg MS, O'Gara S, Olowokure O, Fathallah H, Kozma SC, Thomas G, Rixe O, Desai P, Morris JC. Wise-Draper TM, et al. Among authors: mercer ca. Target Oncol. 2017 Jun;12(3):323-332. doi: 10.1007/s11523-017-0482-9. Target Oncol. 2017. PMID: 28357727 Free PMC article. Clinical Trial.
Mass spectrometry proteomics reveals a function for mammalian CALCOCO1 in MTOR-regulated selective autophagy.
Stefely JA, Zhang Y, Freiberger EC, Kwiecien NW, Thomas HE, Davis AM, Lowry ND, Vincent CE, Shishkova E, Clark NA, Medvedovic M, Coon JJ, Pagliarini DJ, Mercer CA. Stefely JA, et al. Among authors: mercer ca. Autophagy. 2020 Dec;16(12):2219-2237. doi: 10.1080/15548627.2020.1719746. Epub 2020 Feb 2. Autophagy. 2020. PMID: 31971854 Free PMC article.
Mitochondrial Complex I Activity Is Required for Maximal Autophagy.
Thomas HE, Zhang Y, Stefely JA, Veiga SR, Thomas G, Kozma SC, Mercer CA. Thomas HE, et al. Among authors: mercer ca. Cell Rep. 2018 Aug 28;24(9):2404-2417.e8. doi: 10.1016/j.celrep.2018.07.101. Cell Rep. 2018. PMID: 30157433 Free PMC article.
25 results