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The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening.
Patrick R, Naval-Sanchez M, Deshpande N, Huang Y, Zhang J, Chen X, Yang Y, Tiwari K, Esmaeili M, Tran M, Mohamed AR, Wang B, Xia D, Ma J, Bayliss J, Wong K, Hun ML, Sun X, Cao B, Cottle DL, Catterall T, Barzilai-Tutsch H, Troskie RL, Chen Z, Wise AF, Saini S, Soe YM, Kumari S, Sweet MJ, Thomas HE, Smyth IM, Fletcher AL, Knoblich K, Watt MJ, Alhomrani M, Alsanie W, Quinn KM, Merson TD, Chidgey AP, Ricardo SD, Yu D, Jardé T, Cheetham SW, Marcelle C, Nilsson SK, Nguyen Q, White MD, Nefzger CM. Patrick R, et al. Among authors: thomas he. Cell Metab. 2024 Aug 6;36(8):1858-1881.e23. doi: 10.1016/j.cmet.2024.06.006. Epub 2024 Jul 2. Cell Metab. 2024. PMID: 38959897 Free article.
METTL3 restrains autoimmunity in β-cells.
Krishnamurthy B, Thomas HE. Krishnamurthy B, et al. Among authors: thomas he. Nat Cell Biol. 2024 Mar;26(3):321-322. doi: 10.1038/s41556-024-01352-8. Nat Cell Biol. 2024. PMID: 38409326 No abstract available.
Extraislet expression of islet antigen boosts T cell exhaustion to partially prevent autoimmune diabetes.
Selck C, Jhala G, De George DJ, Kwong CJ, Christensen MK, Pappas EG, Liu X, Ge T, Trivedi P, Kallies A, Thomas HE, Kay TWH, Krishnamurthy B. Selck C, et al. Among authors: thomas he. Proc Natl Acad Sci U S A. 2024 Feb 6;121(6):e2315419121. doi: 10.1073/pnas.2315419121. Epub 2024 Jan 29. Proc Natl Acad Sci U S A. 2024. PMID: 38285952 Free PMC article.
Longitudinal Assessment of Pancreas Volume by MRI Predicts Progression to Stage 3 Type 1 Diabetes.
Virostko J, Wright JJ, Williams JM, Hilmes MA, Triolo TM, Broncucia H, Du L, Kang H, Nallaparaju S, Valencia LG, Reyes D, Hammel B, Russell WE, Philipson LH, Waibel M, Kay TWH, Thomas HE, Greeley SAW, Steck AK, Powers AC, Moore DJ. Virostko J, et al. Among authors: thomas he. Diabetes Care. 2024 Mar 1;47(3):393-400. doi: 10.2337/dc23-1681. Diabetes Care. 2024. PMID: 38151474 Free PMC article.
Baricitinib and β-Cell Function in Patients with New-Onset Type 1 Diabetes.
Waibel M, Wentworth JM, So M, Couper JJ, Cameron FJ, MacIsaac RJ, Atlas G, Gorelik A, Litwak S, Sanz-Villanueva L, Trivedi P, Ahmed S, Martin FJ, Doyle ME, Harbison JE, Hall C, Krishnamurthy B, Colman PG, Harrison LC, Thomas HE, Kay TWH; BANDIT Study Group. Waibel M, et al. Among authors: thomas he. N Engl J Med. 2023 Dec 7;389(23):2140-2150. doi: 10.1056/NEJMoa2306691. N Engl J Med. 2023. PMID: 38055252 Clinical Trial.
253 results