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A comparative study of warheads for design of cysteine protease inhibitors.
Silva DG, Ribeiro JFR, De Vita D, Cianni L, Franco CH, Freitas-Junior LH, Moraes CB, Rocha JR, Burtoloso ACB, Kenny PW, Leitão A, Montanari CA. Silva DG, et al. Among authors: cianni l. Bioorg Med Chem Lett. 2017 Nov 15;27(22):5031-5035. doi: 10.1016/j.bmcl.2017.10.002. Epub 2017 Oct 3. Bioorg Med Chem Lett. 2017. PMID: 29054358
Can Cysteine Protease Cross-Class Inhibitors Achieve Selectivity?
Cianni L, Feldmann CW, Gilberg E, Gütschow M, Juliano L, Leitão A, Bajorath J, Montanari CA. Cianni L, et al. J Med Chem. 2019 Dec 12;62(23):10497-10525. doi: 10.1021/acs.jmedchem.9b00683. Epub 2019 Aug 15. J Med Chem. 2019. PMID: 31361135 Review.
Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement.
Gomes JC, Cianni L, Ribeiro J, Dos Reis Rocho F, da Costa Martins Silva S, Batista PHJ, Moraes CB, Franco CH, Freitas-Junior LHG, Kenny PW, Leitão A, Burtoloso ACB, de Vita D, Montanari CA. Gomes JC, et al. Among authors: cianni l. Bioorg Med Chem. 2019 Nov 15;27(22):115083. doi: 10.1016/j.bmc.2019.115083. Epub 2019 Aug 28. Bioorg Med Chem. 2019. PMID: 31561938
Mapping the S1 and S1' subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents.
Cianni L, Lemke C, Gilberg E, Feldmann C, Rosini F, Rocho FDR, Ribeiro JFR, Tezuka DY, Lopes CD, de Albuquerque S, Bajorath J, Laufer S, Leitão A, Gütschow M, Montanari CA. Cianni L, et al. PLoS Negl Trop Dis. 2020 Mar 12;14(3):e0007755. doi: 10.1371/journal.pntd.0007755. eCollection 2020 Mar. PLoS Negl Trop Dis. 2020. PMID: 32163418 Free PMC article.
39 results