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Pulmonary transplantation of alpha-1 antitrypsin (AAT)-transgenic macrophages provides a source of functional human AAT in vivo.
Janosz E, Hetzel M, Spielmann H, Tumpara S, Rossdam C, Schwabbauer M, Kloos D, von Kaisenberg C, Schambach A, Buettner FFR, Janciauskiene S, Lachmann N, Moritz T. Janosz E, et al. Among authors: tumpara s. Gene Ther. 2021 Sep;28(9):477-493. doi: 10.1038/s41434-021-00269-3. Epub 2021 Jul 19. Gene Ther. 2021. PMID: 34276045 Free PMC article. Review.
Alpha-1 antitrypsin deficiency impairs lung antibacterial immunity in mice.
Ostermann L, Maus R, Stolper J, Schütte L, Katsarou K, Tumpara S, Pich A, Mueller C, Janciauskiene S, Welte T, Maus UA. Ostermann L, et al. Among authors: tumpara s. JCI Insight. 2021 Feb 8;6(3):e140816. doi: 10.1172/jci.insight.140816. JCI Insight. 2021. PMID: 33554955 Free PMC article.
Alpha1-antitrypsin binds hemin and prevents oxidative activation of human neutrophils: putative pathophysiological significance.
Janciauskiene S, Tumpara S, Wiese M, Wrenger S, Vijayan V, Gueler F, Chen R, Madyaningrana K, Mahadeva R, Welte T, Immenschuh S, Chorostowska-Wynimko J. Janciauskiene S, et al. Among authors: tumpara s. J Leukoc Biol. 2017 Oct;102(4):1127-1141. doi: 10.1189/jlb.3A0317-124R. Epub 2017 Jul 17. J Leukoc Biol. 2017. PMID: 28716864
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