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Docking of Meprin α to Heparan Sulphate Protects the Endothelium from Inflammatory Cell Extravasation.
Biasin V, Wygrecka M, Bärnthaler T, Jandl K, Jain PP, Bálint Z, Kovacs G, Leitinger G, Kolb-Lenz D, Kornmueller K, Peters F, Sinn K, Klepetko W, Heinemann A, Olschewski A, Becker-Pauly C, Kwapiszewska G. Biasin V, et al. Among authors: peters f. Thromb Haemost. 2018 Oct;118(10):1790-1802. doi: 10.1055/s-0038-1670657. Epub 2018 Sep 20. Thromb Haemost. 2018. PMID: 30235485
Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration.
Bedau T, Peters F, Prox J, Arnold P, Schmidt F, Finkernagel M, Köllmann S, Wichert R, Otte A, Ohler A, Stirnberg M, Lucius R, Koudelka T, Tholey A, Biasin V, Pietrzik CU, Kwapiszewska G, Becker-Pauly C. Bedau T, et al. Among authors: peters f. FASEB J. 2017 Mar;31(3):1226-1237. doi: 10.1096/fj.201601113R. Epub 2016 Dec 21. FASEB J. 2017. PMID: 28003343
Therefore, meprin beta could serve as a therapeutic target, given that in a proof-of-concept approach we showed accumulation of CD99 protein in lungs of meprin beta inhibitor-treated mice.-Bedau, T., Peters, F., Prox, J., Arnold, P., Schmidt, F., Finkernagel, …
Therefore, meprin beta could serve as a therapeutic target, given that in a proof-of-concept approach we showed accumulation of CD99 protein …
Tethering soluble meprin α in an enzyme complex to the cell surface affects IBD-associated genes.
Peters F, Scharfenberg F, Colmorgen C, Armbrust F, Wichert R, Arnold P, Potempa B, Potempa J, Pietrzik CU, Häsler R, Rosenstiel P, Becker-Pauly C. Peters F, et al. FASEB J. 2019 Jun;33(6):7490-7504. doi: 10.1096/fj.201802391R. Epub 2019 Mar 27. FASEB J. 2019. PMID: 30916990 Free PMC article.
Comparison of the transcriptional gene analysis data with gene analyses of IBD patients revealed that different gene subsets were dysregulated if meprin alpha was expressed alone or in the enzyme complex, demonstrating the physiologic and pathophysiological relevance of the mepri …
Comparison of the transcriptional gene analysis data with gene analyses of IBD patients revealed that different gene subsets were dysregulat …
Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro.
Bedau T, Schumacher N, Peters F, Prox J, Arnold P, Koudelka T, Helm O, Schmidt F, Rabe B, Jentzsch M, Rosenstiel P, Sebens S, Tholey A, Rose-John S, Becker-Pauly C. Bedau T, et al. Among authors: peters f. Oncotarget. 2017 Jul 4;8(33):54873-54888. doi: 10.18632/oncotarget.18966. eCollection 2017 Aug 15. Oncotarget. 2017. PMID: 28903388 Free PMC article.
931 results