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238 results

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Buparlisib plus fulvestrant versus placebo plus fulvestrant for postmenopausal, hormone receptor-positive, human epidermal growth factor receptor 2-negative, advanced breast cancer: Overall survival results from BELLE-2.
Campone M, Im SA, Iwata H, Clemons M, Ito Y, Awada A, Chia S, Jagiełło-Gruszfeld A, Pistilli B, Tseng LM, Hurvitz S, Masuda N, Cortés J, De Laurentiis M, Arteaga CL, Jiang Z, Jonat W, Le Mouhaër S, Sankaran B, Bourdeau L, El-Hashimy M, Sellami D, Baselga J. Campone M, et al. Among authors: sankaran b. Eur J Cancer. 2018 Nov;103:147-154. doi: 10.1016/j.ejca.2018.08.002. Epub 2018 Sep 18. Eur J Cancer. 2018. PMID: 30241001 Clinical Trial.
Capmatinib in MET Exon 14-Mutated or MET-Amplified Non-Small-Cell Lung Cancer.
Wolf J, Seto T, Han JY, Reguart N, Garon EB, Groen HJM, Tan DSW, Hida T, de Jonge M, Orlov SV, Smit EF, Souquet PJ, Vansteenkiste J, Hochmair M, Felip E, Nishio M, Thomas M, Ohashi K, Toyozawa R, Overbeck TR, de Marinis F, Kim TM, Laack E, Robeva A, Le Mouhaer S, Waldron-Lynch M, Sankaran B, Balbin OA, Cui X, Giovannini M, Akimov M, Heist RS; GEOMETRY mono-1 Investigators. Wolf J, et al. Among authors: sankaran b. N Engl J Med. 2020 Sep 3;383(10):944-957. doi: 10.1056/NEJMoa2002787. N Engl J Med. 2020. PMID: 32877583 Clinical Trial.
Discovery of highly potent and ALK2/ALK1 selective kinase inhibitors using DNA-encoded chemistry technology.
Jimmidi R, Monsivais D, Ta HM, Sharma KL, Bohren KM, Chamakuri S, Liao Z, Li F, Hakenjos JM, Li JY, Mishina Y, Pan H, Qin X, Robers MB, Sankaran B, Tan Z, Tang S, Vasquez YM, Wilkinson J, Young DW, Palmer SS, MacKenzie KR, Kim C, Matzuk MM. Jimmidi R, et al. Among authors: sankaran b. Proc Natl Acad Sci U S A. 2024 Nov 19;121(47):e2413108121. doi: 10.1073/pnas.2413108121. Epub 2024 Nov 14. Proc Natl Acad Sci U S A. 2024. PMID: 39541346
Rational Exploration of 2,4-Diaminopyrimidines as DHFR Inhibitors Active against Mycobacterium abscessus and Mycobacterium avium, Two Emerging Human Pathogens.
Andrade Meirelles M, Almeida VM, Sullivan JR, de Toledo I, Dos Reis CV, Cunha MR, Zigweid R, Shim A, Sankaran B, Woodward EL, Seibold S, Liu L, Mian MR, Battaile KP, Riley J, Duncan C, Simeons FRC, Ferguson L, Joji H, Read KD, Lovell S, Staker BL, Behr MA, Pilli RA, Couñago RM. Andrade Meirelles M, et al. Among authors: sankaran b. J Med Chem. 2024 Nov 14;67(21):19143-19164. doi: 10.1021/acs.jmedchem.4c01594. Epub 2024 Oct 28. J Med Chem. 2024. PMID: 39468773
Computational design of serine hydrolases.
Lauko A, Pellock SJ, Anischanka I, Sumida KH, Juergens D, Ahern W, Shida A, Hunt A, Kalvet I, Norn C, Humphreys IR, Jamieson C, Kang A, Brackenbrough E, Bera AK, Sankaran B, Houk KN, Baker D. Lauko A, et al. Among authors: sankaran b. bioRxiv [Preprint]. 2024 Aug 30:2024.08.29.610411. doi: 10.1101/2024.08.29.610411. bioRxiv. 2024. PMID: 39257749 Free PMC article. Preprint.
Sculpting conducting nanopore size and shape through de novo protein design.
Berhanu S, Majumder S, Müntener T, Whitehouse J, Berner C, Bera AK, Kang A, Liang B, Khan N, Sankaran B, Tamm LK, Brockwell DJ, Hiller S, Radford SE, Baker D, Vorobieva AA. Berhanu S, et al. Among authors: sankaran b. Science. 2024 Jul 19;385(6706):282-288. doi: 10.1126/science.adn3796. Epub 2024 Jul 18. Science. 2024. PMID: 39024453 Free article.
SARS-CoV-2 Main Protease Inhibitors That Leverage Unique Interactions with the Solvent Exposed S3 Site of the Enzyme.
Blankenship LR, Yang KS, Vulupala VR, Alugubelli YR, Khatua K, Coleman D, Ma XR, Sankaran B, Cho CD, Ma Y, Neuman BW, Xu S, Liu WR. Blankenship LR, et al. Among authors: sankaran b. ACS Med Chem Lett. 2024 May 20;15(6):950-957. doi: 10.1021/acsmedchemlett.4c00146. eCollection 2024 Jun 13. ACS Med Chem Lett. 2024. PMID: 38894905 Free PMC article.
238 results