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Page 1
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells.
Iachettini S, Trisciuoglio D, Rotili D, Lucidi A, Salvati E, Zizza P, Di Leo L, Del Bufalo D, Ciriolo MR, Leonetti C, Steegborn C, Mai A, Rizzo A, Biroccio A. Iachettini S, et al. Cell Death Dis. 2018 Sep 24;9(10):996. doi: 10.1038/s41419-018-1065-0. Cell Death Dis. 2018. PMID: 30250025 Free PMC article.
N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage.
Casagrande V, Salvati E, Alvino A, Bianco A, Ciammaichella A, D'Angelo C, Ginnari-Satriani L, Serrilli AM, Iachettini S, Leonetti C, Neidle S, Ortaggi G, Porru M, Rizzo A, Franceschin M, Biroccio A. Casagrande V, et al. Among authors: iachettini s. J Med Chem. 2011 Mar 10;54(5):1140-56. doi: 10.1021/jm1013665. Epub 2011 Jan 31. J Med Chem. 2011. PMID: 21280624
Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells.
Franceschin M, Rizzo A, Casagrande V, Salvati E, Alvino A, Altieri A, Ciammaichella A, Iachettini S, Leonetti C, Ortaggi G, Porru M, Bianco A, Biroccio A. Franceschin M, et al. Among authors: iachettini s. ChemMedChem. 2012 Dec;7(12):2144-54. doi: 10.1002/cmdc.201200348. Epub 2012 Oct 24. ChemMedChem. 2012. PMID: 23097341
On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts.
Iachettini S, Stevens MF, Frigerio M, Hummersone MG, Hutchinson I, Garner TP, Searle MS, Wilson DW, Munde M, Nanjunda R, D'Angelo C, Zizza P, Rizzo A, Cingolani C, De Cicco F, Porru M, D'Incalci M, Leonetti C, Biroccio A, Salvati E. Iachettini S, et al. J Exp Clin Cancer Res. 2013 Sep 19;32(1):68. doi: 10.1186/1756-9966-32-68. J Exp Clin Cancer Res. 2013. PMID: 24330541 Free PMC article.
Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis.
Salvati E, Zizza P, Rizzo A, Iachettini S, Cingolani C, D'Angelo C, Porru M, Randazzo A, Pagano B, Novellino E, Pisanu ME, Stoppacciaro A, Spinella F, Bagnato A, Gilson E, Leonetti C, Biroccio A. Salvati E, et al. Among authors: iachettini s. Nucleic Acids Res. 2014 Mar;42(5):2945-57. doi: 10.1093/nar/gkt1289. Epub 2013 Dec 11. Nucleic Acids Res. 2014. PMID: 24335081 Free PMC article.
A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds.
Salvati E, Rizzo A, Iachettini S, Zizza P, Cingolani C, D'Angelo C, Porru M, Mondello C, Aiello A, Farsetti A, Gilson E, Leonetti C, Biroccio A. Salvati E, et al. Among authors: iachettini s. Nucleic Acids Res. 2015 Feb 18;43(3):1759-69. doi: 10.1093/nar/gkv006. Epub 2015 Jan 23. Nucleic Acids Res. 2015. PMID: 25618850 Free PMC article.
Erratum: identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities.
Rizzo A, Iachettini S, Zizza P, Cingolani C, Porru M, Artuso S, Stevens M, Hummersone M, Biroccio A, Salvati E, Leonetti C. Rizzo A, et al. Among authors: iachettini s. J Exp Clin Cancer Res. 2015 Feb 5;34(1):9. doi: 10.1186/s13046-014-0101-x. J Exp Clin Cancer Res. 2015. PMID: 25886908 Free PMC article. No abstract available.
25 results