Welch JT - Search Results

1

Efficacy of pyrazinoic acid dry powder aerosols in resolving necrotic and non-necrotic granulomas in a guinea pig model of tuberculosis.

Montgomery SA, Young EF, Durham PG, Zulauf KE, Rank L, Miller BK, Hayden JD, Lin FC, Welch JT, Hickey AJ, Braunstein M. Montgomery SA, et al. Among authors: welch jt. PLoS One. 2018 Sep 27;13(9):e0204495. doi: 10.1371/journal.pone.0204495. eCollection 2018. PLoS One. 2018. PMID: 30261007 Free PMC article.

2

Inhaled Pyrazinoic Acid Esters for the Treatment of Tuberculosis.

Young EF, Perkowski E, Malik S, Hayden JD, Durham PG, Zhong L, Welch JT, Braunstein MS, Hickey AJ. Young EF, et al. Among authors: welch jt. Pharm Res. 2016 Oct;33(10):2495-505. doi: 10.1007/s11095-016-1974-5. Epub 2016 Jun 28. Pharm Res. 2016. PMID: 27351427

3

A dry powder combination of pyrazinoic acid and its n-propyl ester for aerosol administration to animals.

Durham PG, Young EF, Braunstein MS, Welch JT, Hickey AJ. Durham PG, et al. Among authors: welch jt. Int J Pharm. 2016 Dec 5;514(2):384-391. doi: 10.1016/j.ijpharm.2016.04.063. Epub 2016 Apr 26. Int J Pharm. 2016. PMID: 27130363 Free PMC article.

4

Quantitative structure-activity relationships for the in vitro antimycobacterial activity of pyrazinoic acid esters.

Bergmann KE, Cynamon MH, Welch JT. Bergmann KE, et al. Among authors: welch jt. J Med Chem. 1996 Aug 16;39(17):3394-400. doi: 10.1021/jm950538t. J Med Chem. 1996. PMID: 8765523

5

Inhibition of M. tuberculosis in vitro in monocytes and in mice by aminomethylene pyrazinamide analogs.

Chung WJ, Kornilov A, Brodsky BH, Higgins M, Sanchez T, Heifets LB, Cynamon MH, Welch J. Chung WJ, et al. Tuberculosis (Edinb). 2008 Sep;88(5):410-9. doi: 10.1016/j.tube.2008.06.001. Tuberculosis (Edinb). 2008. PMID: 18674969

6

Antimycobacterial activity of a series of pyrazinoic acid esters.

Cynamon MH, Klemens SP, Chou TS, Gimi RH, Welch JT. Cynamon MH, et al. Among authors: welch jt. J Med Chem. 1992 Apr 3;35(7):1212-5. doi: 10.1021/jm00085a007. J Med Chem. 1992. PMID: 1560435

7

Pyrazinoic acid esters with broad spectrum in vitro antimycobacterial activity.

Cynamon MH, Gimi R, Gyenes F, Sharpe CA, Bergmann KE, Han HJ, Gregor LB, Rapolu R, Luciano G, Welch JT. Cynamon MH, et al. Among authors: welch jt. J Med Chem. 1995 Sep 29;38(20):3902-7. doi: 10.1021/jm00020a003. J Med Chem. 1995. PMID: 7562923

8

Pyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosis.

Zimhony O, Cox JS, Welch JT, Vilchèze C, Jacobs WR Jr. Zimhony O, et al. Among authors: welch jt. Nat Med. 2000 Sep;6(9):1043-7. doi: 10.1038/79558. Nat Med. 2000. PMID: 10973326

9

Activity of 5-chloro-pyrazinamide in mice infected with Mycobacterium tuberculosis or Mycobacterium bovis.

Ahmad Z, Tyagi S, Minkowsk A, Almeida D, Nuermberger EL, Peck KM, Welch JT, Baughn AS, Jacobs WR Jr, Grosset JH. Ahmad Z, et al. Among authors: welch jt. Indian J Med Res. 2012 Nov;136(5):808-14. Indian J Med Res. 2012. PMID: 23287128 Free PMC article.

10

Activity of n-propyl pyrazinoate against pyrazinamide-resistant Mycobacterium tuberculosis: investigations into mechanism of action of and mechanism of resistance to pyrazinamide.

Speirs RJ, Welch JT, Cynamon MH. Speirs RJ, et al. Among authors: welch jt. Antimicrob Agents Chemother. 1995 Jun;39(6):1269-71. doi: 10.1128/AAC.39.6.1269. Antimicrob Agents Chemother. 1995. PMID: 7574514 Free PMC article.

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