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Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment.
Molinari A, Fallacara AL, Di Maria S, Zamperini C, Poggialini F, Musumeci F, Schenone S, Angelucci A, Colapietro A, Crespan E, Kissova M, Maga G, Botta M. Molinari A, et al. Among authors: crespan e. Bioorg Med Chem Lett. 2018 Nov 15;28(21):3454-3457. doi: 10.1016/j.bmcl.2018.09.024. Epub 2018 Sep 20. Bioorg Med Chem Lett. 2018. PMID: 30262428
Truncating Variants in RFC1 in Cerebellar Ataxia, Neuropathy, and Vestibular Areflexia Syndrome.
Ronco R, Perini C, Currò R, Dominik N, Facchini S, Gennari A, Simone R, Stuart S, Nagy S, Vegezzi E, Quartesan I, El-Saddig A, Lavin T, Tucci A, Szymura A, Novis De Farias LE, Gary A, Delfeld M, Kandikatla P, Niu N, Tawde S, Shaw J, Polke J, Reilly MM, Wood NW, Crespan E, Gomez C, Chen JYH, Schmahmann JD, Gosal D, Houlden H, Das S, Cortese A. Ronco R, et al. Among authors: crespan e. Neurology. 2023 Jan 31;100(5):e543-e554. doi: 10.1212/WNL.0000000000201486. Epub 2022 Oct 26. Neurology. 2023. PMID: 36289003 Free PMC article.
Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhibition by efavirenz.
Crespan E, Locatelli GA, Cancio R, Hübscher U, Spadari S, Maga G. Crespan E, et al. Antimicrob Agents Chemother. 2005 Jan;49(1):342-9. doi: 10.1128/AAC.49.1.342-349.2005. Antimicrob Agents Chemother. 2005. PMID: 15616314 Free PMC article.
Diketo hexenoic acid derivatives are novel selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases, with potent cytotoxic effect against leukemic cells.
Locatelli GA, Di Santo R, Crespan E, Costi R, Roux A, Hübscher U, Shevelev I, Blanca G, Villani G, Spadari S, Maga G. Locatelli GA, et al. Among authors: crespan e. Mol Pharmacol. 2005 Aug;68(2):538-50. doi: 10.1124/mol.105.013326. Epub 2005 May 18. Mol Pharmacol. 2005. PMID: 15901847
High potency of indolyl aryl sulfone nonnucleoside inhibitors towards drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutants is due to selective targeting of different mechanistic forms of the enzyme.
Cancio R, Silvestri R, Ragno R, Artico M, De Martino G, La Regina G, Crespan E, Zanoli S, Hübscher U, Spadari S, Maga G. Cancio R, et al. Among authors: crespan e. Antimicrob Agents Chemother. 2005 Nov;49(11):4546-54. doi: 10.1128/AAC.49.11.4546-4554.2005. Antimicrob Agents Chemother. 2005. PMID: 16251294 Free PMC article.
Indolyl aryl sulphones as HIV-1 non-nucleoside reverse transcriptase inhibitors: synthesis, biological evaluation and binding mode studies of new derivatives at indole-2-carboxamide.
De Martino G, La Regina G, Ragno R, Coluccia A, Bergamini A, Ciaprini C, Sinistro A, Maga G, Crespan E, Artico M, Silvestri R. De Martino G, et al. Among authors: crespan e. Antivir Chem Chemother. 2006;17(2):59-77. doi: 10.1177/095632020601700202. Antivir Chem Chemother. 2006. PMID: 17042328 Free article.
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