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Page 1
Discovery and lead identification of quinazoline-based BRD4 inhibitors.
Yang SM, Urban DJ, Yoshioka M, Strovel JW, Fletcher S, Wang AQ, Xu X, Shah P, Hu X, Hall MD, Jadhav A, Maloney DJ. Yang SM, et al. Among authors: strovel jw. Bioorg Med Chem Lett. 2018 Nov 15;28(21):3483-3488. doi: 10.1016/j.bmcl.2018.08.039. Epub 2018 Aug 31. Bioorg Med Chem Lett. 2018. PMID: 30268702 Free PMC article.
Predicting Novel Therapies and Targets: Regulation of Notch3 by the Bromodomain Protein BRD4.
Villar-Prados A, Wu SY, Court KA, Ma S, LaFargue C, Chowdhury MA, Engelhardt MI, Ivan C, Ram PT, Wang Y, Baggerly K, Rodriguez-Aguayo C, Lopez-Berestein G, Ming-Yang S, Maloney DJ, Yoshioka M, Strovel JW, Roszik J, Sood AK. Villar-Prados A, et al. Among authors: strovel jw. Mol Cancer Ther. 2019 Feb;18(2):421-436. doi: 10.1158/1535-7163.MCT-18-0365. Epub 2018 Nov 12. Mol Cancer Ther. 2019. PMID: 30420565 Free PMC article.
CG223, a novel BET inhibitor, exerts TGF-β1-mediated antifibrotic effects in a murine model of bleomycin-induced pulmonary fibrosis.
Kaneshita S, Kida T, Yoshioka M, Nishioka K, Raje M, Sakashita A, Hirano A, Sagawa T, Kasahara A, Inoue T, Fujioka K, Nagahara H, Wada M, Kohno M, Strovel JW, Fletcher S, Ashihara E, Kawahito Y. Kaneshita S, et al. Among authors: strovel jw. Pulm Pharmacol Ther. 2021 Oct;70:102057. doi: 10.1016/j.pupt.2021.102057. Epub 2021 Aug 20. Pulm Pharmacol Ther. 2021. PMID: 34425215
AV-65, a novel Wnt/β-catenin signal inhibitor, successfully suppresses progression of multiple myeloma in a mouse model.
Yao H, Ashihara E, Strovel JW, Nakagawa Y, Kuroda J, Nagao R, Tanaka R, Yokota A, Takeuchi M, Hayashi Y, Shimazaki C, Taniwaki M, Strand K, Padia J, Hirai H, Kimura S, Maekawa T. Yao H, et al. Among authors: strovel jw. Blood Cancer J. 2011 Nov;1(11):e43. doi: 10.1038/bcj.2011.41. Epub 2011 Nov 4. Blood Cancer J. 2011. PMID: 22829079 Free PMC article.
Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth.
Mohamed AA, Xavier CP, Sukumar G, Tan SH, Ravindranath L, Seraj N, Kumar V, Sreenath T, McLeod DG, Petrovics G, Rosner IL, Srivastava M, Strovel J, Malhotra SV, LaRonde NA, Dobi A, Dalgard CL, Srivastava S. Mohamed AA, et al. Cancer Res. 2018 Jul 1;78(13):3659-3671. doi: 10.1158/0008-5472.CAN-17-2949. Epub 2018 Apr 30. Cancer Res. 2018. PMID: 29712692
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