Yang SM - Search Results

1

Discovery and lead identification of quinazoline-based BRD4 inhibitors.

Yang SM, Urban DJ, Yoshioka M, Strovel JW, Fletcher S, Wang AQ, Xu X, Shah P, Hu X, Hall MD, Jadhav A, Maloney DJ. Yang SM, et al. Bioorg Med Chem Lett. 2018 Nov 15;28(21):3483-3488. doi: 10.1016/j.bmcl.2018.08.039. Epub 2018 Aug 31. Bioorg Med Chem Lett. 2018. PMID: 30268702 Free PMC article.

2

Simplified staurosporine analogs as potent JAK3 inhibitors.

Yang SM, Malaviya R, Wilson LJ, Argentieri R, Chen X, Yang C, Wang B, Cavender D, Murray WV. Yang SM, et al. Among authors: yang c. Bioorg Med Chem Lett. 2007 Jan 15;17(2):326-31. doi: 10.1016/j.bmcl.2006.10.062. Epub 2006 Oct 26. Bioorg Med Chem Lett. 2007. PMID: 17088059

3

Syntheses and in vitro evaluation of arylsulfone-based MMP inhibitors with heterocycle-derived zinc-binding groups (ZBGs).

Zhang YM, Fan X, Yang SM, Scannevin RH, Burke SL, Rhodes KJ, Jackson PF. Zhang YM, et al. Among authors: yang sm. Bioorg Med Chem Lett. 2008 Jan 1;18(1):405-8. doi: 10.1016/j.bmcl.2007.10.049. Epub 2007 Oct 18. Bioorg Med Chem Lett. 2008. PMID: 17980583

4

beta-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: part 2. Optimization of alpha-amino substituents.

Yang SM, Scannevin RH, Wang B, Burke SL, Huang Z, Karnachi P, Wilson LJ, Rhodes KJ, Lagu B, Murray WV. Yang SM, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1140-5. doi: 10.1016/j.bmcl.2007.11.129. Epub 2007 Dec 5. Bioorg Med Chem Lett. 2008. PMID: 18083558

5

beta-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: part 1. Design, synthesis, and lead identification.

Yang SM, Scannevin RH, Wang B, Burke SL, Wilson LJ, Karnachi P, Rhodes KJ, Lagu B, Murray WV. Yang SM, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1135-9. doi: 10.1016/j.bmcl.2007.11.119. Epub 2007 Dec 5. Bioorg Med Chem Lett. 2008. PMID: 18086526

6

Discovery of novel Cobactin-T based matrix metalloproteinase inhibitors via a ring closing metathesis strategy.

Wilson LJ, Wang B, Yang SM, Scannevin RH, Burke SL, Karnachi P, Rhodes KJ, Murray WV. Wilson LJ, et al. Among authors: yang sm. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6485-90. doi: 10.1016/j.bmcl.2011.08.068. Epub 2011 Aug 28. Bioorg Med Chem Lett. 2011. PMID: 21925881

7

4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: urea-based analogs.

Yang SM, Tang Y, Zhang R, Lu H, Kuo GH, Gaul MD, Li Y, Ho G, Conway JG, Liang Y, Lenhard JM, Demarest KT, Murray WV. Yang SM, et al. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6773-6. doi: 10.1016/j.bmcl.2013.09.096. Epub 2013 Oct 9. Bioorg Med Chem Lett. 2013. PMID: 24153205

8

4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: part 2. Pyridazine-based analogs.

Yang SM, Tang Y, Rano T, Lu H, Kuo GH, Gaul MD, Li Y, Ho G, Lang W, Conway JG, Liang Y, Lenhard JM, Demarest KT, Murray WV. Yang SM, et al. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1437-41. doi: 10.1016/j.bmcl.2013.12.075. Epub 2013 Dec 27. Bioorg Med Chem Lett. 2014. PMID: 24405703

9

Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1).

Yang SM, Yasgar A, Miller B, Lal-Nag M, Brimacombe K, Hu X, Sun H, Wang A, Xu X, Nguyen K, Oppermann U, Ferrer M, Vasiliou V, Simeonov A, Jadhav A, Maloney DJ. Yang SM, et al. J Med Chem. 2015 Aug 13;58(15):5967-78. doi: 10.1021/acs.jmedchem.5b00577. Epub 2015 Jul 24. J Med Chem. 2015. PMID: 26207746 Free PMC article.

10

A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models.

Martinez NJ, Rai G, Yasgar A, Lea WA, Sun H, Wang Y, Luci DK, Yang SM, Nishihara K, Takeda S, Sagor M, Earnshaw I, Okada T, Mori K, Wilson K, Riggins GJ, Xia M, Grimaldi M, Jadhav A, Maloney DJ, Simeonov A. Martinez NJ, et al. Among authors: yang sm. PLoS One. 2016 Aug 29;11(8):e0161486. doi: 10.1371/journal.pone.0161486. eCollection 2016. PLoS One. 2016. PMID: 27570969 Free PMC article.

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