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Identification of a Potent Cytotoxic Pyrazole with Anti-Breast Cancer Activity That Alters Multiple Pathways.
Gutierrez DA, Contreras L, Villanueva PJ, Borrego EA, Morán-Santibañez K, Hess JD, DeJesus R, Larragoity M, Betancourt AP, Mohl JE, Robles-Escajeda E, Begum K, Roy S, Kirken RA, Varela-Ramirez A, Aguilera RJ. Gutierrez DA, et al. Among authors: villanueva pj. Cells. 2022 Jan 12;11(2):254. doi: 10.3390/cells11020254. Cells. 2022. PMID: 35053370 Free PMC article.
A new pyridazinone exhibits potent cytotoxicity on human cancer cells via apoptosis and poly-ubiquitinated protein accumulation.
Gutierrez DA, DeJesus RE, Contreras L, Rodriguez-Palomares IA, Villanueva PJ, Balderrama KS, Monterroza L, Larragoity M, Varela-Ramirez A, Aguilera RJ. Gutierrez DA, et al. Among authors: villanueva pj. Cell Biol Toxicol. 2019 Dec;35(6):503-519. doi: 10.1007/s10565-019-09466-8. Epub 2019 Mar 1. Cell Biol Toxicol. 2019. PMID: 30825052 Free PMC article.