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Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging.
Gustafson JL, Neklesa TK, Cox CS, Roth AG, Buckley DL, Tae HS, Sundberg TB, Stagg DB, Hines J, McDonnell DP, Norris JD, Crews CM. Gustafson JL, et al. Among authors: mcdonnell dp. Angew Chem Int Ed Engl. 2015 Aug 10;54(33):9659-62. doi: 10.1002/anie.201503720. Epub 2015 Jun 17. Angew Chem Int Ed Engl. 2015. PMID: 26083457 Free PMC article.
Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer.
Pollock JA, Wardell SE, Parent AA, Stagg DB, Ellison SJ, Alley HM, Chao CA, Lawrence SA, Stice JP, Spasojevic I, Baker JG, Kim SH, McDonnell DP, Katzenellenbogen JA, Norris JD. Pollock JA, et al. Among authors: mcdonnell dp. Nat Chem Biol. 2016 Oct;12(10):795-801. doi: 10.1038/nchembio.2131. Epub 2016 Aug 8. Nat Chem Biol. 2016. PMID: 27501397 Free PMC article.
Androgen receptor monomers and dimers regulate opposing biological processes in prostate cancer cells.
Safi R, Wardell SE, Watkinson P, Qin X, Lee M, Park S, Krebs T, Dolan EL, Blattler A, Tsuji T, Nayak S, Khater M, Fontanillo C, Newlin MA, Kirkland ML, Xie Y, Long H, Fink EC, Fanning SW, Runyon S, Brown M, Xu S, Owzar K, Norris JD, McDonnell DP. Safi R, et al. Among authors: mcdonnell dp. Nat Commun. 2024 Sep 3;15(1):7675. doi: 10.1038/s41467-024-52032-y. Nat Commun. 2024. PMID: 39227594 Free PMC article.
Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands.
Norris JD, Joseph JD, Sherk AB, Juzumiene D, Turnbull PS, Rafferty SW, Cui H, Anderson E, Fan D, Dye DA, Deng X, Kazmin D, Chang CY, Willson TM, McDonnell DP. Norris JD, et al. Among authors: mcdonnell dp. Chem Biol. 2009 Apr 24;16(4):452-60. doi: 10.1016/j.chembiol.2009.01.016. Chem Biol. 2009. PMID: 19389631 Free PMC article.
289 results