Ruan J - Search Results

1

Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1.

Li Y, Fu TM, Lu A, Witt K, Ruan J, Shen C, Wu H. Li Y, et al. Among authors: ruan j. Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):10845-10852. doi: 10.1073/pnas.1810524115. Epub 2018 Oct 2. Proc Natl Acad Sci U S A. 2018. PMID: 30279182 Free PMC article.

2

Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes.

Lu A, Magupalli VG, Ruan J, Yin Q, Atianand MK, Vos MR, Schröder GF, Fitzgerald KA, Wu H, Egelman EH. Lu A, et al. Among authors: ruan j. Cell. 2014 Mar 13;156(6):1193-1206. doi: 10.1016/j.cell.2014.02.008. Cell. 2014. PMID: 24630722 Free PMC article.

3

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.

Zhang L, Chen S, Ruan J, Wu J, Tong AB, Yin Q, Li Y, David L, Lu A, Wang WL, Marks C, Ouyang Q, Zhang X, Mao Y, Wu H. Zhang L, et al. Among authors: ruan j. Science. 2015 Oct 23;350(6259):404-9. doi: 10.1126/science.aac5789. Epub 2015 Oct 8. Science. 2015. PMID: 26449474 Free PMC article.

4

Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2.

Lu A, Li Y, Yin Q, Ruan J, Yu X, Egelman E, Wu H. Lu A, et al. Among authors: ruan j. Cell Discov. 2015;1:15013-. doi: 10.1038/celldisc.2015.13. Epub 2015 Jun 23. Cell Discov. 2015. PMID: 26583071 Free PMC article.

5

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly.

Schmidt FI, Lu A, Chen JW, Ruan J, Tang C, Wu H, Ploegh HL. Schmidt FI, et al. Among authors: ruan j. J Exp Med. 2016 May 2;213(5):771-90. doi: 10.1084/jem.20151790. Epub 2016 Apr 11. J Exp Med. 2016. PMID: 27069117 Free PMC article.

6

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells.

Zanoni I, Tan Y, Di Gioia M, Broggi A, Ruan J, Shi J, Donado CA, Shao F, Wu H, Springstead JR, Kagan JC. Zanoni I, et al. Among authors: ruan j. Science. 2016 Jun 3;352(6290):1232-6. doi: 10.1126/science.aaf3036. Epub 2016 Apr 21. Science. 2016. PMID: 27103670 Free PMC article.

7

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.

Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu H, Lieberman J. Liu X, et al. Among authors: ruan j. Nature. 2016 Jul 7;535(7610):153-8. doi: 10.1038/nature18629. Nature. 2016. PMID: 27383986 Free PMC article.

8

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages.

Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC. Evavold CL, et al. Among authors: ruan j. Immunity. 2018 Jan 16;48(1):35-44.e6. doi: 10.1016/j.immuni.2017.11.013. Epub 2017 Nov 28. Immunity. 2018. PMID: 29195811 Free PMC article.

9

Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2.

Annibaldi A, Wicky John S, Vanden Berghe T, Swatek KN, Ruan J, Liccardi G, Bianchi K, Elliott PR, Choi SM, Van Coillie S, Bertin J, Wu H, Komander D, Vandenabeele P, Silke J, Meier P. Annibaldi A, et al. Among authors: ruan j. Mol Cell. 2018 Feb 15;69(4):566-580.e5. doi: 10.1016/j.molcel.2018.01.027. Mol Cell. 2018. PMID: 29452637 Free PMC article.

10

Cryo-EM structure of the gasdermin A3 membrane pore.

Ruan J, Xia S, Liu X, Lieberman J, Wu H. Ruan J, et al. Nature. 2018 May;557(7703):62-67. doi: 10.1038/s41586-018-0058-6. Epub 2018 Apr 25. Nature. 2018. PMID: 29695864 Free PMC article.

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