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Targeting XRCC1 deficiency in breast cancer for personalized therapy.
Sultana R, Abdel-Fatah T, Abbotts R, Hawkes C, Albarakati N, Seedhouse C, Ball G, Chan S, Rakha EA, Ellis IO, Madhusudan S. Sultana R, et al. Among authors: seedhouse c. Cancer Res. 2013 Mar 1;73(5):1621-34. doi: 10.1158/0008-5472.CAN-12-2929. Epub 2012 Dec 19. Cancer Res. 2013. PMID: 23253910
Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors.
Sultana R, McNeill DR, Abbotts R, Mohammed MZ, Zdzienicka MZ, Qutob H, Seedhouse C, Laughton CA, Fischer PM, Patel PM, Wilson DM 3rd, Madhusudan S. Sultana R, et al. Among authors: seedhouse c. Int J Cancer. 2012 Nov 15;131(10):2433-44. doi: 10.1002/ijc.27512. Epub 2012 Mar 28. Int J Cancer. 2012. PMID: 22377908 Free PMC article.
Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy.
Albarakati N, Abdel-Fatah TM, Doherty R, Russell R, Agarwal D, Moseley P, Perry C, Arora A, Alsubhi N, Seedhouse C, Rakha EA, Green A, Ball G, Chan S, Caldas C, Ellis IO, Madhusudan S. Albarakati N, et al. Among authors: seedhouse c. Mol Oncol. 2015 Jan;9(1):204-17. doi: 10.1016/j.molonc.2014.08.001. Epub 2014 Aug 27. Mol Oncol. 2015. PMID: 25205036 Free PMC article. Clinical Trial.
Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy.
Abbotts R, Jewell R, Nsengimana J, Maloney DJ, Simeonov A, Seedhouse C, Elliott F, Laye J, Walker C, Jadhav A, Grabowska A, Ball G, Patel PM, Newton-Bishop J, Wilson DM 3rd, Madhusudan S. Abbotts R, et al. Among authors: seedhouse c. Oncotarget. 2014 May 30;5(10):3273-86. doi: 10.18632/oncotarget.1926. Oncotarget. 2014. PMID: 24830350 Free PMC article.
59 results