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Integration of genomics, high throughput drug screening, and personalized xenograft models as a novel precision medicine paradigm for high risk pediatric cancer.
Tsoli M, Wadham C, Pinese M, Failes T, Joshi S, Mould E, Yin JX, Gayevskiy V, Kumar A, Kaplan W, Ekert PG, Saletta F, Franshaw L, Liu J, Gifford A, Weber MA, Rodriguez M, Cohn RJ, Arndt G, Tyrrell V, Haber M, Trahair T, Marshall GM, McDonald K, Cowley MJ, Ziegler DS. Tsoli M, et al. Among authors: failes t. Cancer Biol Ther. 2018;19(12):1078-1087. doi: 10.1080/15384047.2018.1491498. Epub 2018 Oct 9. Cancer Biol Ther. 2018. PMID: 30299205 Free PMC article.
Comparative drug screening in NUT midline carcinoma.
Beesley AH, Stirnweiss A, Ferrari E, Endersby R, Howlett M, Failes TW, Arndt GM, Charles AK, Cole CH, Kees UR. Beesley AH, et al. Among authors: failes tw. Br J Cancer. 2014 Mar 4;110(5):1189-98. doi: 10.1038/bjc.2014.54. Epub 2014 Feb 11. Br J Cancer. 2014. PMID: 24518598 Free PMC article.
High-Content Imaging of Unbiased Chemical Perturbations Reveals that the Phenotypic Plasticity of the Actin Cytoskeleton Is Constrained.
Bryce NS, Failes TW, Stehn JR, Baker K, Zahler S, Arzhaeva Y, Bischof L, Lyons C, Dedova I, Arndt GM, Gaus K, Goult BT, Hardeman EC, Gunning PW, Lock JG. Bryce NS, et al. Among authors: failes tw. Cell Syst. 2019 Nov 27;9(5):496-507.e5. doi: 10.1016/j.cels.2019.09.002. Epub 2019 Oct 9. Cell Syst. 2019. PMID: 31606369 Free article.
Exploiting the reactive oxygen species imbalance in high-risk paediatric acute lymphoblastic leukaemia through auranofin.
Karsa M, Kosciolek A, Bongers A, Mariana A, Failes T, Gifford AJ, Kees UR, Cheung LC, Kotecha RS, Arndt GM, Haber M, Norris MD, Sutton R, Lock RB, Henderson MJ, Somers K. Karsa M, et al. Among authors: failes t. Br J Cancer. 2021 Jul;125(1):55-64. doi: 10.1038/s41416-021-01332-x. Epub 2021 Apr 9. Br J Cancer. 2021. PMID: 33837299 Free PMC article.
Combination efficacy of ruxolitinib with standard-of-care drugs in CRLF2-rearranged Ph-like acute lymphoblastic leukemia.
Bӧhm JW, Sia KCS, Jones C, Evans K, Mariana A, Pang I, Failes T, Zhong L, Mayoh C, Landman R, Collins R, Erickson SW, Arndt G, Raftery MJ, Wilkins MR, Norris MD, Haber M, Marshall GM, Lock RB. Bӧhm JW, et al. Among authors: failes t. Leukemia. 2021 Nov;35(11):3101-3112. doi: 10.1038/s41375-021-01248-8. Epub 2021 Apr 24. Leukemia. 2021. PMID: 33895784
30 results