Decreased LIN28B in preeclampsia impairs human trophoblast differentiation and migration.
Canfield J, Arlier S, Mong EF, Lockhart J, VanWye J, Guzeloglu-Kayisli O, Schatz F, Magness RR, Lockwood CJ, Tsibris JCM, Kayisli UA, Totary-Jain H.
Canfield J, et al.
FASEB J. 2019 Feb;33(2):2759-2769. doi: 10.1096/fj.201801163R. Epub 2018 Oct 11.
FASEB J. 2019.
PMID: 30307771
Free PMC article.
These results provide the first evidence that LIN28B is the predominant paralog in human placenta and that decreased LIN28B may play a role in PE by reducing trophoblast invasion and syncytialization, and by promoting inflammation.-Canfield, J., Arlier, S., Mong, E. …
These results provide the first evidence that LIN28B is the predominant paralog in human placenta and that decreased LIN28B may play a role …