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Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles.
Bioorg Med Chem. 2018 Nov 1;26(20):5408-5419. doi: 10.1016/j.bmc.2018.09.004. Epub 2018 Sep 5.
Bioorg Med Chem. 2018.
PMID: 30322754
Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages.
Tran TT, Mathmann CD, Gatica-Andrades M, Rollo RF, Oelker M, Ljungberg JK, Nguyen TTK, Zamoshnikova A, Kummari LK, Wyer OJK, Irvine KM, Melo-Bolívar J, Gross A, Brown D, Mak JYW, Fairlie DP, Hansford KA, Cooper MA, Giri R, Schreiber V, Joseph SR, Simpson F, Barnett TC, Johansson J, Dankers W, Harris J, Wells TJ, Kapetanovic R, Sweet MJ, Latomanski EA, Newton HJ, Guérillot RJR, Hachani A, Stinear TP, Ong SY, Chandran Y, Hartland EL, Kobe B, Stow JL, Sauer-Eriksson AE, Begun J, Kling JC, Blumenthal A.
Tran TT, et al. Among authors: kummari lk.
PLoS Pathog. 2022 Jan 10;18(1):e1010166. doi: 10.1371/journal.ppat.1010166. eCollection 2022 Jan.
PLoS Pathog. 2022.
PMID: 35007292
Free PMC article.
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2-[2-(4-(trifluoromethyl)phenylamino)thiazol-4-yl]acetic acid (Activator-3) is a potent activator of AMPK.
Bung N, Surepalli S, Seshadri S, Patel S, Peddasomayajula S, Kummari LK, Kumar ST, Babu PP, Parsa KVL, Poondra RR, Bulusu G, Misra P.
Bung N, et al. Among authors: kummari lk.
Sci Rep. 2018 Jun 25;8(1):9599. doi: 10.1038/s41598-018-27974-1.
Sci Rep. 2018.
PMID: 29942003
Free PMC article.
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