Chen Y - Search Results

1

Assessment of OATP transporter-mediated drug-drug interaction using physiologically-based pharmacokinetic (PBPK) modeling - a case example.

Chen Y, Zhu R, Ma F, Mao J, Chen EC, Choo EF, Sahasranaman S, Liu L. Chen Y, et al. Among authors: chen ec. Biopharm Drug Dispos. 2018 Nov;39(9):420-430. doi: 10.1002/bdd.2159. Epub 2018 Nov 20. Biopharm Drug Dispos. 2018. PMID: 30335192

2

Determination of time-dependent inactivation of CYP3A4 in cryopreserved human hepatocytes and assessment of human drug-drug interactions.

Chen Y, Liu L, Monshouwer M, Fretland AJ. Chen Y, et al. Drug Metab Dispos. 2011 Nov;39(11):2085-92. doi: 10.1124/dmd.111.040634. Epub 2011 Aug 11. Drug Metab Dispos. 2011. PMID: 21835977

3

Application of IVIVE and PBPK modeling in prospective prediction of clinical pharmacokinetics: strategy and approach during the drug discovery phase with four case studies.

Chen Y, Jin JY, Mukadam S, Malhi V, Kenny JR. Chen Y, et al. Biopharm Drug Dispos. 2012 Mar;33(2):85-98. doi: 10.1002/bdd.1769. Epub 2012 Jan 24. Biopharm Drug Dispos. 2012. PMID: 22228214

4

Physiologically based pharmacokinetic modeling as a tool to predict drug interactions for antibody-drug conjugates.

Chen Y, Samineni D, Mukadam S, Wong H, Shen BQ, Lu D, Girish S, Hop C, Jin JY, Li C. Chen Y, et al. Clin Pharmacokinet. 2015 Jan;54(1):81-93. doi: 10.1007/s40262-014-0182-x. Clin Pharmacokinet. 2015. PMID: 25223698

5

Physiologically based pharmacokinetic modeling to predict drug-drug interactions involving inhibitory metabolite: a case study of amiodarone.

Chen Y, Mao J, Hop CE. Chen Y, et al. Drug Metab Dispos. 2015 Feb;43(2):182-9. doi: 10.1124/dmd.114.059311. Epub 2014 Oct 16. Drug Metab Dispos. 2015. PMID: 25324279 Clinical Trial.

6

Development of a Physiologically Based Pharmacokinetic Model for Itraconazole Pharmacokinetics and Drug-Drug Interaction Prediction.

Chen Y, Ma F, Lu T, Budha N, Jin JY, Kenny JR, Wong H, Hop CE, Mao J. Chen Y, et al. Clin Pharmacokinet. 2016 Jun;55(6):735-49. doi: 10.1007/s40262-015-0352-5. Clin Pharmacokinet. 2016. PMID: 26692192

7

Evaluation of Time Dependent Inhibition Assays for Marketed Oncology Drugs: Comparison of Human Hepatocytes and Liver Microsomes in the Presence and Absence of Human Plasma.

Mao J, Tay S, Khojasteh CS, Chen Y, Hop CE, Kenny JR. Mao J, et al. Among authors: chen y. Pharm Res. 2016 May;33(5):1204-19. doi: 10.1007/s11095-016-1865-9. Epub 2016 Feb 11. Pharm Res. 2016. PMID: 26869174

8

Simultaneous determination of itraconazole, hydroxy itraconazole, keto itraconazole and N-desalkyl itraconazole concentration in human plasma using liquid chromatography with tandem mass spectrometry.

Liang X, Van Parys M, Ding X, Zeng N, Bi L, Dorshort D, McKnight J, Milanowski D, Mao J, Chen Y, Ware JA, Dean B, Hop CE, Deng Y. Liang X, et al. Among authors: chen y. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 May 1;1020:111-9. doi: 10.1016/j.jchromb.2016.03.039. Epub 2016 Mar 26. J Chromatogr B Analyt Technol Biomed Life Sci. 2016. PMID: 27038403

9

Evaluation of Cytochrome P450 3A4-Mediated Drug-Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation.

Budha NR, Ji T, Musib L, Eppler S, Dresser M, Chen Y, Jin JY. Budha NR, et al. Among authors: chen y. Clin Pharmacokinet. 2016 Nov;55(11):1435-1445. doi: 10.1007/s40262-016-0412-5. Clin Pharmacokinet. 2016. PMID: 27225997

10

A supported liquid extraction LC-MS/MS method for determination of concentrations of GDC-0425, a small molecule Checkpoint kinase 1 inhibitor, in human plasma.

Ding X, Chen Y, Sahasranaman S, Shi Y, McKnight J, Dean B. Ding X, et al. Among authors: chen y. Biomed Chromatogr. 2016 Dec;30(12):1984-1991. doi: 10.1002/bmc.3775. Epub 2016 Jul 5. Biomed Chromatogr. 2016. PMID: 27245274

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