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Atypical activation of the G protein Gαq by the oncogenic mutation Q209P.
Maziarz M, Leyme A, Marivin A, Luebbers A, Patel PP, Chen Z, Sprang SR, Garcia-Marcos M. Maziarz M, et al. Among authors: leyme a. J Biol Chem. 2018 Dec 21;293(51):19586-19599. doi: 10.1074/jbc.RA118.005291. Epub 2018 Oct 23. J Biol Chem. 2018. PMID: 30352874 Free PMC article.
Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif.
de Opakua AI, Parag-Sharma K, DiGiacomo V, Merino N, Leyme A, Marivin A, Villate M, Nguyen LT, de la Cruz-Morcillo MA, Blanco-Canosa JB, Ramachandran S, Baillie GS, Cerione RA, Blanco FJ, Garcia-Marcos M. de Opakua AI, et al. Among authors: leyme a. Nat Commun. 2017 May 18;8:15163. doi: 10.1038/ncomms15163. Nat Commun. 2017. PMID: 28516903 Free PMC article.
Specific inhibition of GPCR-independent G protein signaling by a rationally engineered protein.
Leyme A, Marivin A, Maziarz M, DiGiacomo V, Papakonstantinou MP, Patel PP, Blanco-Canosa JB, Walawalkar IA, Rodriguez-Davila G, Dominguez I, Garcia-Marcos M. Leyme A, et al. Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10319-E10328. doi: 10.1073/pnas.1707992114. Epub 2017 Nov 13. Proc Natl Acad Sci U S A. 2017. PMID: 29133411 Free PMC article.
17 results