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Mitochondrial apoptosis is induced by Alkoxy phenyl-1-propanone derivatives through PP2A-mediated dephosphorylation of Bad and Foxo3A in CLL.
Pagano MA, Tibaldi E, Molino P, Frezzato F, Trimarco V, Facco M, Zagotto G, Ribaudo G, Leanza L, Peruzzo R, Szabò I, Visentin A, Frasson M, Semenzato G, Trentin L, Brunati AM. Pagano MA, et al. Among authors: peruzzo r. Leukemia. 2019 May;33(5):1148-1160. doi: 10.1038/s41375-018-0288-5. Epub 2018 Oct 23. Leukemia. 2019. PMID: 30353029
Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo.
Leanza L, Romio M, Becker KA, Azzolini M, Trentin L, Managò A, Venturini E, Zaccagnino A, Mattarei A, Carraretto L, Urbani A, Kadow S, Biasutto L, Martini V, Severin F, Peruzzo R, Trimarco V, Egberts JH, Hauser C, Visentin A, Semenzato G, Kalthoff H, Zoratti M, Gulbins E, Paradisi C, Szabo I. Leanza L, et al. Among authors: peruzzo r. Cancer Cell. 2017 Apr 10;31(4):516-531.e10. doi: 10.1016/j.ccell.2017.03.003. Cancer Cell. 2017. PMID: 28399409 Free article.
Mitochondrial potassium channels in cell death.
Checchetto V, Azzolini M, Peruzzo R, Capitanio P, Leanza L. Checchetto V, et al. Among authors: peruzzo r. Biochem Biophys Res Commun. 2018 May 27;500(1):51-58. doi: 10.1016/j.bbrc.2017.06.095. Epub 2017 Jun 19. Biochem Biophys Res Commun. 2018. PMID: 28642134 Review.
Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family.
Peruzzo R, Mattarei A, Azzolini M, Becker-Flegler KA, Romio M, Rigoni G, Carrer A, Biasutto L, Parrasia S, Kadow S, Managò A, Urbani A, Rossa A, Semenzato G, Soriano ME, Trentin L, Ahmad S, Edwards M, Gulbins E, Paradisi C, Zoratti M, Leanza L, Szabò I. Peruzzo R, et al. Redox Biol. 2020 Oct;37:101705. doi: 10.1016/j.redox.2020.101705. Epub 2020 Sep 6. Redox Biol. 2020. PMID: 33007503 Free PMC article.
Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction.
Costa R, Peruzzo R, Bachmann M, Montà GD, Vicario M, Santinon G, Mattarei A, Moro E, Quintana-Cabrera R, Scorrano L, Zeviani M, Vallese F, Zoratti M, Paradisi C, Argenton F, Brini M, Calì T, Dupont S, Szabò I, Leanza L. Costa R, et al. Among authors: peruzzo r. Cell Rep. 2019 Aug 20;28(8):1949-1960.e6. doi: 10.1016/j.celrep.2019.07.050. Cell Rep. 2019. PMID: 31433973 Free article.
Corrigendum to "Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family" [Redox Biol. 37 (2020 Sep 6) 101705-101721].
Peruzzo R, Mattarei A, Azzolini M, Becker-Flegler KA, Romio M, Rigoni G, Carrer A, Biasutto L, Parrasia S, Kadow S, Managò A, Urbani A, Rossa A, Semenzato G, Soriano ME, Trentin L, Ahmad S, Edwards M, Gulbins E, Paradisi C, Zoratti M, Leanza L, Szabò I. Peruzzo R, et al. Redox Biol. 2021 Sep;45:102036. doi: 10.1016/j.redox.2021.102036. Epub 2021 Jun 29. Redox Biol. 2021. PMID: 34210643 Free PMC article. No abstract available.
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