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TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation.
Zhang CJ, Jiang M, Zhou H, Liu W, Wang C, Kang Z, Han B, Zhang Q, Chen X, Xiao J, Fisher A, Kaiser WJ, Murayama MA, Iwakura Y, Gao J, Carman J, Dongre A, Dubyak G, Abbott DW, Shi FD, Ransohoff RM, Li X. Zhang CJ, et al. Among authors: kaiser wj. J Clin Invest. 2018 Dec 3;128(12):5399-5412. doi: 10.1172/JCI121901. Epub 2018 Oct 29. J Clin Invest. 2018. PMID: 30372424 Free PMC article.
T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis.
Martin BN, Wang C, Zhang CJ, Kang Z, Gulen MF, Zepp JA, Zhao J, Bian G, Do JS, Min B, Pavicic PG Jr, El-Sanadi C, Fox PL, Akitsu A, Iwakura Y, Sarkar A, Wewers MD, Kaiser WJ, Mocarski ES, Rothenberg ME, Hise AG, Dubyak GR, Ransohoff RM, Li X. Martin BN, et al. Among authors: kaiser wj. Nat Immunol. 2016 May;17(5):583-92. doi: 10.1038/ni.3389. Epub 2016 Mar 21. Nat Immunol. 2016. PMID: 26998763 Free PMC article.
Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling.
Antonopoulos C, Russo HM, El Sanadi C, Martin BN, Li X, Kaiser WJ, Mocarski ES, Dubyak GR. Antonopoulos C, et al. Among authors: kaiser wj. J Biol Chem. 2015 Aug 14;290(33):20167-84. doi: 10.1074/jbc.M115.652321. Epub 2015 Jun 22. J Biol Chem. 2015. PMID: 26100631 Free PMC article.
ZBP1/DAI Drives RIPK3-Mediated Cell Death Induced by IFNs in the Absence of RIPK1.
Ingram JP, Thapa RJ, Fisher A, Tummers B, Zhang T, Yin C, Rodriguez DA, Guo H, Lane R, Williams R, Slifker MJ, Basagoudanavar SH, Rall GF, Dillon CP, Green DR, Kaiser WJ, Balachandran S. Ingram JP, et al. Among authors: kaiser wj. J Immunol. 2019 Sep 1;203(5):1348-1355. doi: 10.4049/jimmunol.1900216. Epub 2019 Jul 29. J Immunol. 2019. PMID: 31358656 Free PMC article.
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation.
Jiao H, Wachsmuth L, Kumari S, Schwarzer R, Lin J, Eren RO, Fisher A, Lane R, Young GR, Kassiotis G, Kaiser WJ, Pasparakis M. Jiao H, et al. Among authors: kaiser wj. Nature. 2020 Apr;580(7803):391-395. doi: 10.1038/s41586-020-2129-8. Epub 2020 Mar 25. Nature. 2020. PMID: 32296175 Free PMC article.
Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner.
Bossaller L, Chiang PI, Schmidt-Lauber C, Ganesan S, Kaiser WJ, Rathinam VA, Mocarski ES, Subramanian D, Green DR, Silverman N, Fitzgerald KA, Marshak-Rothstein A, Latz E. Bossaller L, et al. Among authors: kaiser wj. J Immunol. 2012 Dec 15;189(12):5508-12. doi: 10.4049/jimmunol.1202121. Epub 2012 Nov 9. J Immunol. 2012. PMID: 23144495 Free PMC article.
Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1β production in response to β-glucans and the fungal pathogen, Candida albicans.
Ganesan S, Rathinam VAK, Bossaller L, Army K, Kaiser WJ, Mocarski ES, Dillon CP, Green DR, Mayadas TN, Levitz SM, Hise AG, Silverman N, Fitzgerald KA. Ganesan S, et al. Among authors: kaiser wj. J Immunol. 2014 Sep 1;193(5):2519-2530. doi: 10.4049/jimmunol.1400276. Epub 2014 Jul 25. J Immunol. 2014. PMID: 25063877 Free PMC article.
119 results