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TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation.
Zhang CJ, Jiang M, Zhou H, Liu W, Wang C, Kang Z, Han B, Zhang Q, Chen X, Xiao J, Fisher A, Kaiser WJ, Murayama MA, Iwakura Y, Gao J, Carman J, Dongre A, Dubyak G, Abbott DW, Shi FD, Ransohoff RM, Li X. Zhang CJ, et al. Among authors: zhang q. J Clin Invest. 2018 Dec 3;128(12):5399-5412. doi: 10.1172/JCI121901. Epub 2018 Oct 29. J Clin Invest. 2018. PMID: 30372424 Free PMC article.
T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis.
Martin BN, Wang C, Zhang CJ, Kang Z, Gulen MF, Zepp JA, Zhao J, Bian G, Do JS, Min B, Pavicic PG Jr, El-Sanadi C, Fox PL, Akitsu A, Iwakura Y, Sarkar A, Wewers MD, Kaiser WJ, Mocarski ES, Rothenberg ME, Hise AG, Dubyak GR, Ransohoff RM, Li X. Martin BN, et al. Among authors: zhang cj. Nat Immunol. 2016 May;17(5):583-92. doi: 10.1038/ni.3389. Epub 2016 Mar 21. Nat Immunol. 2016. PMID: 26998763 Free PMC article.
Act1 is a negative regulator in T and B cells via direct inhibition of STAT3.
Zhang CJ, Wang C, Jiang M, Gu C, Xiao J, Chen X, Martin BN, Tang F, Yamamoto E, Xian Y, Wang H, Li F, Sartor RB, Smith H, Husni ME, Shi FD, Gao J, Carman J, Dongre A, McKarns SC, Coppieters K, Jørgensen TN, Leonard WJ, Li X. Zhang CJ, et al. Nat Commun. 2018 Jul 16;9(1):2745. doi: 10.1038/s41467-018-04974-3. Nat Commun. 2018. PMID: 30013031 Free PMC article.
IL-17R-EGFR axis links wound healing to tumorigenesis in Lrig1+ stem cells.
Chen X, Cai G, Liu C, Zhao J, Gu C, Wu L, Hamilton TA, Zhang CJ, Ko J, Zhu L, Qin J, Vidimos A, Koyfman S, Gastman BR, Jensen KB, Li X. Chen X, et al. Among authors: zhang cj. J Exp Med. 2019 Jan 7;216(1):195-214. doi: 10.1084/jem.20171849. Epub 2018 Dec 21. J Exp Med. 2019. PMID: 30578323 Free PMC article.
757 results