Mbonye U - Search Results

1

Exosomes derived from HIV-1-infected cells promote growth and progression of cancer via HIV TAR RNA.

Chen L, Feng Z, Yue H, Bazdar D, Mbonye U, Zender C, Harding CV, Bruggeman L, Karn J, Sieg SF, Wang B, Jin G. Chen L, et al. Among authors: mbonye u. Nat Commun. 2018 Nov 2;9(1):4585. doi: 10.1038/s41467-018-07006-2. Nat Commun. 2018. PMID: 30389917 Free PMC article.

2

T-cell receptor signaling enhances transcriptional elongation from latent HIV proviruses by activating P-TEFb through an ERK-dependent pathway.

Kim YK, Mbonye U, Hokello J, Karn J. Kim YK, et al. Among authors: mbonye u. J Mol Biol. 2011 Jul 29;410(5):896-916. doi: 10.1016/j.jmb.2011.03.054. J Mol Biol. 2011. PMID: 21763495 Free PMC article.

3

Control of HIV latency by epigenetic and non-epigenetic mechanisms.

Mbonye U, Karn J. Mbonye U, et al. Curr HIV Res. 2011 Dec 1;9(8):554-67. doi: 10.2174/157016211798998736. Curr HIV Res. 2011. PMID: 22211660 Free PMC article.

4

Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes.

Mbonye UR, Gokulrangan G, Datt M, Dobrowolski C, Cooper M, Chance MR, Karn J. Mbonye UR, et al. PLoS Pathog. 2013;9(5):e1003338. doi: 10.1371/journal.ppat.1003338. Epub 2013 May 2. PLoS Pathog. 2013. PMID: 23658523 Free PMC article. Clinical Trial.

5

Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure.

Mbonye U, Karn J. Mbonye U, et al. Virology. 2014 Apr;454-455:328-39. doi: 10.1016/j.virol.2014.02.008. Epub 2014 Feb 22. Virology. 2014. PMID: 24565118 Free PMC article. Review.

6

Phosphorylation of HEXIM1 at Tyr271 and Tyr274 Promotes Release of P-TEFb from the 7SK snRNP Complex and Enhances Proviral HIV Gene Expression.

Mbonye UR, Wang B, Gokulrangan G, Chance MR, Karn J. Mbonye UR, et al. Proteomics. 2015 Jun;15(12):2078-86. doi: 10.1002/pmic.201500038. Epub 2015 May 15. Proteomics. 2015. PMID: 25900325 Free PMC article.

7

The Molecular Basis for Human Immunodeficiency Virus Latency.

Mbonye U, Karn J. Mbonye U, et al. Annu Rev Virol. 2017 Sep 29;4(1):261-285. doi: 10.1146/annurev-virology-101416-041646. Epub 2017 Jul 17. Annu Rev Virol. 2017. PMID: 28715973 Review.

8

The KAT5-Acetyl-Histone4-Brd4 axis silences HIV-1 transcription and promotes viral latency.

Li Z, Mbonye U, Feng Z, Wang X, Gao X, Karn J, Zhou Q. Li Z, et al. Among authors: mbonye u. PLoS Pathog. 2018 Apr 23;14(4):e1007012. doi: 10.1371/journal.ppat.1007012. eCollection 2018 Apr. PLoS Pathog. 2018. PMID: 29684085 Free PMC article.

9

Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation.

Mbonye U, Wang B, Gokulrangan G, Shi W, Yang S, Karn J. Mbonye U, et al. J Biol Chem. 2018 Jun 29;293(26):10009-10025. doi: 10.1074/jbc.RA117.001347. Epub 2018 May 9. J Biol Chem. 2018. PMID: 29743242 Free PMC article.

10

Biogenesis of P-TEFb in CD4+ T cells to reverse HIV latency is mediated by protein kinase C (PKC)-independent signaling pathways.

Mbonye U, Leskov K, Shukla M, Valadkhan S, Karn J. Mbonye U, et al. PLoS Pathog. 2021 Sep 16;17(9):e1009581. doi: 10.1371/journal.ppat.1009581. eCollection 2021 Sep. PLoS Pathog. 2021. PMID: 34529720 Free PMC article.

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